Affiliation:
1. Department of Chemistry College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan University Guangzhou 510632 China
2. Department of Orthopedics Affiliated Hospital of Guangdong Medical University Zhanjiang 524001 China
Abstract
AbstractFacilely synthesized nanoradiosensitizers with well‐controlled structure and multifunctionality are greatly desired to address the challenges of cancer radiotherapy. In this work, a universal method is developed for synthesizing chalcogen‐based TeSe nano‐heterojunctions (NHJs) with rod‐, spindle‐, or dumbbell‐like morphologies by engineering the surfactant and added selenite. Interestingly, dumbbell‐shaped TeSe NHJs (TeSe NDs) as chaperone exhibit better radio‐sensitizing activities than the other two nanostructural shapes. Meanwhile, TeSe NDs can serve as cytotoxic chemodrugs that degrade to highly toxic metabolites in acidic environment and deplete GSH within tumor to facilitate radiotherapy. More importantly, the combination of TeSe NDs with radiotherapy significantly decreases regulatory T cells and M2‐phenotype tumor‐associated macrophage infiltrations within tumors to reshape the immunosuppressive microenvironment and induce robust T lymphocytes‐mediated antitumor immunity, resulting in great abscopal effects on combating distant tumor progression. This study provides a universal method for preparing NHJ with well‐controlled structure and developing nanoradiosensitizers to overcome the clinical challenges of cancer radiotherapy.
Funder
National Natural Science Foundation of China
Shenzhen Fundamental Research Program
China Postdoctoral Science Foundation
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
8 articles.
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