Ultrasound‐Driven Non‐Metallic Fenton‐Active Center Construction for Extensive Chemodynamic Therapy

Author:

Wu Jiyue12,Meng Yun3,Wu Fan1,Shi Jieyun3,Sun Qingwen1,Jiang Xingwu1,Liu Yanyan1,Zhao Peiran1,Wang Qiao3,Guo Lehang3,Wu Yelin3,Zheng Xiangpeng2,Bu Wenbo12ORCID

Affiliation:

1. Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers Academy for Engineering and Technology Fudan University Shanghai 200438 P. R. China

2. Department of Radiation Oncology Huadong Hospital Affiliated to Fudan University Shanghai 200040 P. R. China

3. Department of Medical Ultrasound Shanghai Tenth People's Hospital Tongji University Cancer Center Tongji University School of Medicine Shanghai 200072 P. R. China

Abstract

AbstractChemodynamic therapy (CDT) is an emerging tumor microenvironment‐responsive cancer therapeutic strategy based on Fenton/Fenton‐like reactions. However, the effectiveness of CDT is subject to the slow kinetic rate and non‐homogeneous distribution of H2O2. In this study, a conceptual non‐metallic “Fenton‐active” center construction strategy is proposed to enhance CDT efficiency using Bi0.44Ba0.06Na0.5TiO2.97 (BNBT‐6) nanocrystals. The separated charge carriers under a piezoelectric‐induced electric field synchronize the oxidation of H2O and reduction of H2O2, which consequently increases hydroxyl radical (·OH) yield even under low H2O2 levels. Moreover, acceptor doping induces electron‐rich oxygen vacancies to facilitate the dissociation of H2O2 and H2O and further promote ·OH generation. In vitro and in vivo experiments demonstrate that BNBT‐6 induces extensive intracellular oxidative stress and enhances cell‐killing efficiency by activating necroptosis in addition to the conventional apoptotic pathway. This study proposes a novel design approach for nanomaterials used in CDT and presents a new treatment strategy for apoptosis‐resistant tumors.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3