Encoded Structural Color Microneedle Patches for Multiple Screening of Wound Small Molecules

Author:

Lu Minhui1ORCID,Zhang Xiaoxuan1,Xu Dongyu1,Li Ning1,Zhao Yuanjin23ORCID

Affiliation:

1. Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 P. R. China

2. Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health) Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang 325001 P. R. China

3. Chemistry and Biomedicine Innovation Center Nanjing University Nanjing 210023 China

Abstract

AbstractDetection of biomarkers associated with wound conditions provides in‐depth healthcare information and benefits wound healing treatment. The current aim of wound detection is to achieve in situ multiple detections. Novel encoded structural color microneedle patches (EMNs) combining photonic crystals (PhCs) and microneedle arrays (MNs) for multiple wound biomarker detection in situ are described here. Using a partitioned and layered casting strategy, the EMNs can be divided into different modules and each serves for the detection of small molecules , including pH, glucose, and histamine. pH sensing is based on the interaction between hydrogen ions and carboxyl groups from hydrolyzed polyacrylamide (PAM); glucose sensing is achieved with the help of glucose‐responsive fluorophenylboronic acid (FPBA); while histamine sensing relies on specific recognition of aptamers and target molecules. Owing to the responsive volume change of these three modules in the presence of target molecules, the EMNs can create structural color change and characteristic peak shift of the PhCs, thus realizing the qualitative measurement of target molecules with a spectrum analyzer. It is further demonstrated that the EMNs behave well in the multivariate detection of rat wound molecules. These features indicate that the EMNs can be valuable smart detection systems for wound status screening.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Shenzhen Fundamental Research Program

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

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