Microfluidic Templated Stem Cell Spheroid Microneedles for Diabetic Wound Treatment

Author:

Wu Xiangyi1,Huang Danqing1,Xu Ye1,Chen Guopu1,Zhao Yuanjin123ORCID

Affiliation:

1. Department of Burn and Plastic Surgery Institute of Translational Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210002 China

2. State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China

3. Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine Vision and Brain Health) Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang 325001 China

Abstract

AbstractWound dressing patches based on stem cells have demonstrated promising potential in the treatment of diabetic wounds, while their capabilities in the maintenance of cell stemness, effective exchange of cellular substance, and precise targeting of the stem cells remain to be promoted. Here, a novel stem cell spheroid loaded microneedle (MN@SPs) patch is presented using microfluidic templating technology. By leveraging the precise fluid manipulation capabilities of the microfluidic template, stem cell spheroids (SPs) with uniform size can be generated in situ. The resulting SPs exhibit advanced viability and cell functions, as evidenced by the overexpressed genes related to extracellular matrix organization and angiogenesis. By loading these SPs into the microneedles (MNs), the platform enables the precise delivery and exchange of multiple active substances, which contribute to advanced neovascularization, collagen deposition, and tissue reconstruction of diabetic wounds. Overall, this microfluidic‐engineered stem cell therapy platform demonstrates significant promise in promoting wound healing.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Nanjing Medical Science and Technique Development Foundation

Shenzhen Fundamental Research Program

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

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