Metal‐Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction

Author:

Vecchioni Simon1ORCID,Lu Brandon1ORCID,Livernois William2ORCID,Ohayon Yoel P.1ORCID,Yoder Jesse B.3ORCID,Yang Chu‐Fan1ORCID,Woloszyn Karol1ORCID,Bernfeld William14ORCID,Anantram M. P.2ORCID,Canary James W.1ORCID,Hendrickson Wayne A.5ORCID,Rothschild Lynn J.6ORCID,Mao Chengde7ORCID,Wind Shalom J.8ORCID,Seeman Nadrian C.1ORCID,Sha Ruojie1ORCID

Affiliation:

1. Department of Chemistry New York University New York NY 10003 USA

2. Department of Electrical and Computer Engineering University of Washington Seattle WA 98195 USA

3. IMCA‐CAT Argonne National Lab Argonne IL 60439 USA

4. ASPIRE Program King School Stamford CT 06905 USA

5. Department of Biochemistry and Molecular Biophysics Columbia University New York NY 10032 USA

6. NASA Ames Research Center Planetary Sciences Branch Moffett Field CA 94035 USA

7. Department of Chemistry Purdue University West Lafayette IN 47907 USA

8. Department of Applied Physics and Applied Math Columbia University New York NY 10027 USA

Abstract

AbstractDNA double helices containing metal‐mediated DNA (mmDNA) base pairs are constructed from Ag+ and Hg2+ ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials is impractical without a complete lexical and structural description. Here, the programmability of structural DNA nanotechnology toward its founding mission of self‐assembling a diffraction platform for biomolecular structure determination is explored. The tensegrity triangle is employed to build a comprehensive structural library of mmDNA pairs via X‐ray diffraction and generalized design rules for mmDNA construction are elucidated. Two binding modes are uncovered: N3‐dominant, centrosymmetric pairs and major groove binders driven by 5‐position ring modifications. Energy gap calculations show additional levels in the lowest unoccupied molecular orbitals (LUMO) of mmDNA structures, rendering them attractive molecular electronic candidates.

Funder

Office of Naval Research

U.S. Department of Energy

National Science Foundation

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3