Affiliation:
1. Division of Vascular & Interventional Radiology Laboratory for Patient Inspired Engineering Mayo Clinic 13400 East Shea Blvd. Scottsdale AZ 85259 USA
2. Chair Emeritus Division of Vascular and Endovascular Surgery Emeritus Professor of Surgery Mayo Clinic 5777 East Mayo Blvd. Phoenix AZ 85054 USA
3. Department of Neurological Surgery and Radiology Mayo Clinic 5777 East Mayo Blvd. Phoenix AZ 85054 USA
Abstract
AbstractRuptured wide‐neck aneurysms (WNAs), especially in a setting of coagulopathy, are associated with significant morbidity and mortality. It is shown that by trapping a sub‐millimeter clinical catheter inside the aneurysm sac using a flow diverter stent (FDS), instant hemostasis can be achieved by filling the aneurysm sac using a novel biomaterial, rescuing catastrophic bleeding in large‐animal models. Multiple formulations of a biomaterial comprising gelatin, nanoclay (NC), and iohexol are developed, optimized, and extensively tested in vitro to select the lead candidate for further testing in vivo in murine, porcine, and canine models of WNAs, including in a subset with aneurysm rupture. The catheter‐injectable and X‐ray visible versions of the gel embolic agent (GEA) with the optimized mechanical properties outperform control groups, including a subset that receive a clinically used liquid embolic (Onyx, Medtronic), with and without aneurysm rupture. A combinatorial approach to ruptured WNAs with GEA and FDS may change the standard of medical practice and save lives.
Funder
National Institutes of Health
Mayo Clinic
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
2 articles.
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