Affiliation:
1. College of Engineering and Applied Sciences National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Centre Collaborative Innovation Centre of Advanced Microstructures Nanjing University Nanjing 210023 China
2. Key Laboratory of Inflammation and Immunoregulation School of Medicine and Holistic Integrative Medicine Nanjing University of Chinese Medicine Nanjing 210023 China
Abstract
AbstractDiseases in pregnancy endanger millions of fetuses worldwide every year. The onset of these diseases can be early warned by the dynamic abnormalities of biochemicals in amniotic fluid, thus requiring real‐time monitoring. However, when continuously penetrated by detection devices, the amnion is prone to loss of robustness and rupture, which is difficult to regenerate. Here, an interface‐stabilized fiber sensor is presented for real‐time monitoring of biochemical dynamics in amniotic fluid during pregnancy. The sensor is seamlessly integrated into the amnion through tissue adhesion, amniotic regeneration, and uniform stress distribution, posing no risk to the amniotic fluid environment. The sensor demonstrates a response performance of less than 0.3% fluctuation under complex dynamic conditions and an accuracy of more than 98% from the second to the third trimester. By applying it to early warning of diseases such as intrauterine hypoxia, intrauterine infection, and fetal growth restriction, fetal survival increases to 95% with timely intervention.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Jiangsu Postdoctoral Research Foundation
China Postdoctoral Science Foundation
National Postdoctoral Program for Innovative Talents
Natural Science Foundation of Jiangsu Province
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
1 articles.
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