Affiliation:
1. The Shmunis School of Biomedicine and Cancer Research Faculty of Life Sciences Tel Aviv University Tel Aviv 6997801 Israel
2. Department of Biomedical Engineering Faculty of Engineering Tel Aviv University Tel Aviv 6997801 Israel
3. The Sagol Center for Regenerative Biotechnology Tel Aviv University Tel Aviv 6997801 Israel
4. Tel Aviv University Center for Nanoscience & Nanotechnology The Chaoul Center for Nanoscale Systems Tel Aviv University Tel Aviv 6997801 Israel
Abstract
AbstractDespite advances in biomaterials engineering, a large gap remains between the weak mechanical properties that can be achieved with natural materials and the strength of synthetic materials. Here, a method is presented for reinforcing an engineered cardiac tissue fabricated from differentiated induced pluripotent stem cells (iPSCs) and an extracellular matrix (ECM)‐based hydrogel in a manner that is fully biocompatible. The reinforcement occurs as a post‐fabrication step, which allows for the use of 3D‐printing technology to generate thick, fully cellularized, and vascularized cardiac tissues. After tissue assembly and during the maturation process in a soft hydrogel, a small, tissue‐penetrating reinforcer is deployed, leading to a significant increase in the tissue's mechanical properties. The tissue's robustness is demonstrated by injecting the tissue in a simulated minimally invasive procedure and showing that the tissue is functional and undamaged at the nano‐, micro‐, and macroscales.
Funder
Nicholas and Elizabeth Slezak Super Center for Cardiac Research and Biomedical Engineering
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
4 articles.
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