Affiliation:
1. Shaanxi Eastantai Pharmaceutical Co. Ltd Xianyang Shaanxi Province China
2. Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese Medicine Xi’an Shaanxi Province China
3. State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation) Shaanxi University of Chinese Medicine Xi’an Shaanxi Province China
4. Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research Shaanxi University of Chinese Medicine Xi’an Shaanxi Province China
Abstract
AbstractMedical abortion is a common medical procedure that women choose to terminate an unwanted pregnancy, but it often brings post‐abortion complications. Danggui (Angelica sinensis Radix)–Yimucao (Leonuri Herba), as a herbal pair (DY) in clinical prescriptions of traditional Chinese medicine, is often used in the treatment of gynecological diseases and has the traditional functions of tonifying the blood, promoting blood circulation, removing blood stasis and regulating menstruation. In this study, serum lipidomics were adopted to dissect the mechanism of DY in promoting recovery after medical abortion. A total of 152 differential metabolites were screened by lipidomics. All metabolites were imported into MetaboAnalyst for analysis, and finally key metabolic pathways such as glycerophospholipid metabolism, linoleic acid metabolism and pentose and glucuronate interconversions were enriched. Our results indicated that metabolic disorders in abortion mice were alleviated by DY through glycerophospholipid metabolism, while prostaglandin and leukotriene metabolites might be the key targets of DY to promote post‐abortion recovery.
Funder
National Natural Science Foundation of China
Key Research and Development Projects of Shaanxi Province
Subject
Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry