Comparison of Remimazolam and Propofol for Drug‐Induced Sleep Endoscopy: A Randomized Clinical Trial

Author:

Zhang Jianxi1,Zhang Yiying1,Fang Xing23,Weng Lili1,Zhu Sha1,Luo Ning12,Huang Donghai23,Guo Qulian12,Huang Changsheng12ORCID

Affiliation:

1. Department of Anesthesiology Xiangya Hospital Central South University Changsha China

2. National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha China

3. Department of Otolaryngology–Head and Neck Surgery, Xiangya Hospital Central South University Changsha China

Abstract

AbstractObjectiveTo compare the efficacy and safety of remimazolam with those of propofol for drug‐induced sleep endoscopy (DISE) in patients with obstructive sleep apnea‐hypopnea syndrome (OSAHS).Study DesignA prospective, single‐center, randomized clinical trial.SettingXiangya Hospital of Central South University.MethodsPatients with OSAHS receiving DISE were randomly assigned to either the remimazolam or propofol group. The primary outcome was the incidence of hypoxemia (pulse oxygen saturation [SpO2] < 90%) during DISE. The secondary outcomes were the incidence of severe hypoxemia (SpO2 < 80%), the minimal value of SpO2, sedation success rate (completion of DISE according to the medication regimen), and incidence of events of interest (including injection pain, bradycardia, and decreased respiratory rate).ResultsSixty‐four patients were included in this study. The incidence of hypoxemia was significantly lower in the remimazolam than in the propofol group (25.00% vs 62.50%, respectively; relative risk, 0.40; 95% confidence interval [CI], 0.20‐0.74; p < .01). There was no significant difference in the sedation success rate between the remimazolam and propofol groups (96.88% vs 81.25%, respectively; relative risk, 1.19; 95% CI, 1.01‐1.50; p = .10). The incidence of at least 1 event of interest was lower in the remimazolam than in the propofol group (43.75% vs 96.88%, respectively; relative risk, 0.45; 95% CI, 0.29‐0.63; p < .01).ConclusionRemimazolam can present satisfactory sedative efficacy in DISE, with a lower incidence of hypoxemia and a higher safety profile than propofol.

Publisher

Wiley

Subject

Otorhinolaryngology,Surgery

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3