Mutational spectrum in a worldwide study of 29,700 families withBRCA1orBRCA2mutations-Reference-Cited by-同舟云学术

Mutational spectrum in a worldwide study of 29,700 families withBRCA1orBRCA2mutations

Published:2018-03-12 Issue:5 Volume:39 Page:593-620
ISSN:1059-7794
Container-title:Human Mutation
language:en
Short-container-title:Human Mutation

Author:

Rebbeck Timothy R.¹,Friebel Tara M.¹,Friedman Eitan²,Hamann Ute³,Huo Dezheng⁴,Kwong Ava⁵,Olah Edith⁶,Olopade Olufunmilayo I.⁴,Solano Angela R.⁷,Teo Soo-Hwang⁸,Thomassen Mads⁹,Weitzel Jeffrey N.¹⁰,Chan TL¹¹,Couch Fergus J.¹²,Goldgar David E.¹³,Kruse Torben A.⁹,Palmero Edenir Inêz¹⁴,Park Sue Kyung¹⁵¹⁶¹⁷,Torres Diana³¹⁸,van Rensburg Elizabeth J.¹⁹,McGuffog Lesley²⁰,Parsons Michael T.²¹,Leslie Goska²⁰,Aalfs Cora M.²²,Abugattas Julio²³,Adlard Julian²⁴,Agata Simona²⁵,Aittomäki Kristiina²⁶,Andrews Lesley²⁷,Andrulis Irene L.²⁸²⁹,Arason Adalgeir³⁰,Arnold Norbert³¹,Arun Banu K.³²,Asseryanis Ella³³,Auerbach Leo³³,Azzollini Jacopo³⁴,Balmaña Judith³⁵,Barile Monica³⁶,Barkardottir Rosa B.³⁰,Barrowdale Daniel²⁰,Benitez Javier³⁷³⁸,Berger Andreas³⁹,Berger Raanan⁴⁰,Blanco Amie M.⁴¹,Blazer Kathleen R.¹⁰,Blok Marinus J.⁴²,Bonadona Valérie⁴³,Bonanni Bernardo³⁶,Bradbury Angela R.⁴⁴,Brewer Carole⁴⁵,Buecher Bruno⁴⁶,Buys Saundra S.⁴⁷,Caldes Trinidad⁴⁸,Caliebe Almuth⁴⁹,Caligo Maria A.⁵⁰,Campbell Ian⁵¹,Caputo Sandrine M.⁴⁶,Chiquette Jocelyne⁵²,Chung Wendy K.⁵³,Claes Kathleen B.M.⁵⁴,Collée J. Margriet⁵⁵,Cook Jackie⁵⁶,Davidson Rosemarie⁵⁷,de la Hoya Miguel⁴⁸,De Leeneer Kim⁵⁴,de Pauw Antoine⁴⁶,Delnatte Capucine⁵⁸,Diez Orland⁵⁹,Ding Yuan Chun⁶⁰,Ditsch Nina⁶¹,Domchek Susan M.⁴⁴,Dorfling Cecilia M.¹⁹,Velazquez Carolina⁶²,Dworniczak Bernd⁶³,Eason Jacqueline⁶⁴,Easton Douglas F.²⁰,Eeles Ros⁶⁵,Ehrencrona Hans⁶⁶,Ejlertsen Bent⁶⁷,Engel Christoph⁶⁸,Engert Stefanie⁶⁹,Evans D. Gareth⁷⁰,Faivre Laurence⁷¹,Feliubadaló Lidia⁷²,Ferrer Sandra Fert⁷³,Foretova Lenka⁷⁴,Fowler Jeffrey⁷⁵,Frost Debra²⁰,Galvão Henrique C. R.⁷⁶,Ganz Patricia A.⁷⁷,Garber Judy⁷⁸,Gauthier-Villars Marion⁴⁶,Gehrig Andrea⁷⁹,Gerdes Anne-Marie⁸⁰,Gesta Paul⁸¹,Giannini Giuseppe⁸²,Giraud Sophie⁸³,Glendon Gord⁸⁴,Godwin Andrew K.⁸⁵,Greene Mark H.⁸⁶,Gronwald Jacek⁸⁷,Gutierrez-Barrera Angelica³²,Hahnen Eric⁸⁸,Hauke Jan⁸⁸,Henderson Alex⁸⁹,Hentschel Julia⁹⁰,Hogervorst Frans B.L.⁹¹,Honisch Ellen⁹²,Imyanitov Evgeny N.⁹³,Isaacs Claudine⁹⁴,Izatt Louise⁹⁵,Izquierdo Angel⁹⁶,Jakubowska Anna⁸⁷,James Paul⁹⁷,Janavicius Ramunas⁹⁸,Jensen Uffe Birk⁹⁹,John Esther M.¹⁰⁰¹⁰¹,Vijai Joseph¹⁰²,Kaczmarek Katarzyna⁸⁷,Karlan Beth Y.¹⁰³,Kast Karin¹⁰⁴,Investigators KConFab¹⁰⁵,Kim Sung-Won¹⁰⁶,Konstantopoulou Irene¹⁰⁷,Korach Jacob¹⁰⁸,Laitman Yael²,Lasa Adriana¹⁰⁹,Lasset Christine⁴³,Lázaro Conxi⁷²,Lee Annette¹¹⁰,Lee Min Hyuk¹¹¹,Lester Jenny¹⁰³,Lesueur Fabienne¹¹²,Liljegren Annelie¹¹³,Lindor Noralane M.¹¹⁴,Longy Michel¹¹⁵,Loud Jennifer T.¹¹⁶,Lu Karen H.¹¹⁷,Lubinski Jan⁸⁷,Machackova Eva⁷⁴,Manoukian Siranoush³⁴,Mari Véronique¹¹⁸,Martínez-Bouzas Cristina¹¹⁹,Matrai Zoltan¹²⁰,Mebirouk Noura¹¹²,Meijers-Heijboer Hanne E.J.¹²¹,Meindl Alfons⁶⁹,Mensenkamp Arjen R.¹²²,Mickys Ugnius¹²³,Miller Austin¹²⁴,Montagna Marco²⁵,Moysich Kirsten B.¹²⁵,Mulligan Anna Marie¹²⁶,Musinsky Jacob¹⁰²,Neuhausen Susan L.⁶⁰,Nevanlinna Heli¹²⁷,Ngeow Joanne¹²⁸,Nguyen Huu Phuc¹²⁹,Niederacher Dieter⁹²,Nielsen Henriette Roed⁹,Nielsen Finn Cilius¹³⁰,Nussbaum Robert L.¹³¹,Offit Kenneth¹³²,Öfverholm Anna¹³³,Ong Kai-ren¹³⁴,Osorio Ana¹³⁵,Papi Laura¹³⁶,Papp Janos⁶,Pasini Barbara¹³⁷,Pedersen Inge Sokilde¹³⁸,Peixoto Ana¹³⁹¹⁴⁰,Peruga Nina⁸⁷,Peterlongo Paolo¹⁴¹,Pohl Esther⁸⁸,Pradhan Nisha¹⁰²,Prajzendanc Karolina⁸⁷,Prieur Fabienne¹⁴²,Pujol Pascal¹⁴³,Radice Paolo¹⁴⁴,Ramus Susan J.¹⁴⁵¹⁴⁶,Rantala Johanna¹⁴⁷,Rashid Muhammad Usman³¹⁴⁸,Rhiem Kerstin⁸⁸,Robson Mark¹⁴⁹,Rodriguez Gustavo C.¹⁵⁰,Rogers Mark T.¹⁵¹,Rudaitis Vilius¹⁵²,Schmidt Ane Y.¹³⁰,Schmutzler Rita Katharina⁸⁸,Senter Leigha¹⁵³,Shah Payal D.⁴⁴,Sharma Priyanka¹⁵⁴,Side Lucy E.¹⁵⁵,Simard Jacques¹⁵⁶,Singer Christian F.³³,Skytte Anne-Bine⁹⁹,Slavin Thomas P.¹⁰,Snape Katie¹⁵⁷,Sobol Hagay¹⁵⁸,Southey Melissa¹⁵⁸¹⁵⁹,Steele Linda⁶⁰,Steinemann Doris¹⁶⁰,Sukiennicki Grzegorz⁸⁷,Sutter Christian¹⁶¹,Szabo Csilla I.¹⁶²,Tan Yen Y.³⁹,Teixeira Manuel R.¹³⁹¹⁴⁰,Terry Mary Beth¹⁶³,Teulé Alex¹⁶⁴,Thomas Abigail¹⁶⁵,Thull Darcy L.¹⁶⁶,Tischkowitz Marc¹⁶⁷,Tognazzo Silvia²⁵,Toland Amanda Ewart¹⁶⁸,Topka Sabine¹⁰²,Trainer Alison H¹⁶⁹,Tung Nadine¹⁷⁰,van Asperen Christi J.¹⁷¹,van der Hout Annemieke H.¹⁷²,van der Kolk Lizet E.⁹¹,van der Luijt Rob B.¹⁷³,Van Heetvelde Mattias⁵⁴,Varesco Liliana¹⁷⁴,Varon-Mateeva Raymonda¹⁷⁵,Vega Ana¹⁷⁶,Villarreal-Garza Cynthia¹⁷⁷¹⁷⁸,von Wachenfeldt Anna¹⁷⁹,Walker Lisa¹⁸⁰,Wang-Gohrke Shan¹⁸¹,Wappenschmidt Barbara⁸⁸,Weber Bernhard H. F.¹⁸²,Yannoukakos Drakoulis¹⁰⁷,Yoon Sook-Yee⁸,Zanzottera Cristina³⁴,Zidan Jamal¹⁸³,Zorn Kristin K.¹⁸⁴,Hutten Selkirk Christina G.¹⁸⁵,Hulick Peter J.¹⁸⁶,Chenevix-Trench Georgia²¹,Spurdle Amanda B.²¹,Antoniou Antonis C.²⁰,Nathanson Katherine L.⁴⁴, , ,

Affiliation:

1. Harvard TH Chan School of Public Health and Dana Farber Cancer Institute; Boston USA

2. The Susanne Levy Gertner Oncogenetics Unit; Institute of Human Genetics; Chaim Sheba Medical Center, Ramat Gan 52621, and the Sackler School of Medicine; Tel-Aviv University; Tel-Aviv Israel

3. Molecular Genetics of Breast Cancer; German Cancer Research Center (DKFZ); Heidelberg Germany

4. Center for Clinical Cancer Genetics and Global Health; University of Chicago; Chicago USA

5. The Hong Kong Hereditary Breast Cancer Family Registry; Cancer Genetics Center; Hong Kong Sanatorium and Hospital; Hong Kong China

6. Department of Molecular Genetics; National Institute of Oncology; Budapest Hungary

7. INBIOMED; Faculty of Medicine, University of Buenos Aires/CONICET and CEMIC, Department of Clinical Chemistry; Medical Direction; Buenos Aires Argentina

8. Cancer Research Initiatives Foundation; Sime Darby Medical Centre; Subang Jaya Malaysia

9. Department of Clinical Genetics; Odense University Hospital; Odense Denmark

10. Division of Clinical Cancer Genomics; City of Hope Cancer Center; California USA

11. Division of Molecular Pathology; Department of Pathology; Hong Kong Sanatorium & Hospital; Happy Valley Hong Kong

12. Department of Laboratory Medicine and Pathology; and Health Sciences Research; Rochester USA

13. Department of Dermatology; University of Utah School of Medicine; Salt Lake City USA

14. Molecular Oncology Research Center; Barretos Cancer Hospital; São Paulo Brazil

15. Department of Preventive Medicine; Seoul National University College of Medicine; Seoul Korea

16. Department of Biomedical Science; Seoul National University Graduate School; Seoul Korea

17. Cancer Research Center; Seoul National University; Seoul Korea

18. Institute of Human Genetics; Pontificia Universidad Javeriana; Colombia

19. Cancer Genetics Laboratory, Department of Genetics; University of Pretoria; South Africa

20. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care; University of Cambridge; Cambridge UK

21. Genetics and Computational Biology Department; QIMR Berghofer Medical Research Institute; Brisbane Australia

22. Department of Clinical Genetics; Academic Medical Center; Amsterdam The Netherlands

23. City of Hope Clinical Cancer Genomics Community Research Network; Duarte USA

24. Yorkshire Regional Genetics Service; Chapel Allerton Hospital; Leeds UK

25. Immunology and Molecular Oncology Unit; Veneto Institute of Oncology IOV - IRCCS; Padua Italy

26. Department of Clinical Genetics; Helsinki University Hospital; Helsinki Finland

27. Hereditary Cancer Clinic; Prince of Wales Hospital; Randwick Australia

28. Lunenfeld-Tanenbaum Research Institute; Toronto Canada

29. Department of Molecular Genetics; University of Toronto; Toronto Canada

30. Laboratory of Cell Biology, Department of Pathology, hus 9, Landspitali-LSH v/Hringbraut, 101 Reykjavik, Iceland and BMC (Biomedical Centre), Faculty of Medicine; University of Iceland; Reykjavik Iceland

31. Department of Gynaecology & Oncology; Medical University of Vienna; Austria

32. Department of Breast Medical Oncology and Clinical Cancer Genetics Program; University Of Texas MD Anderson Cancer Center; Houston USA

33. Dept of OB/GYN and Comprehensive Cancer Center; Medical University of Vienna; Vienna Austria

34. Unit of Medical Genetics, Department of Medical Oncology and Hematology; Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Instituto Nazionale Tumori (INT); Milan Italy

35. Department of Medical Oncology; Vall d'Hebron University Hospital; Barcelona Spain

36. Division of Cancer Prevention and Genetics; Istituto Europeo di Oncologia (IEO); Milan Italy

37. Human Genetics Group and Genotyping Unit (CEGEN), Human Cancer Genetics Programme; Spanish National Cancer Research Centre (CNIO); Madrid Spain

38. Biomedical Network on Rare Diseases (CIBERER); Madrid Spain

39. Dept of OB/GYN, Comprehensive Cancer Center; Medical University of Vienna; Vienna Austria

40. The Institute of Oncology; Chaim Sheba Medical Center; Ramat Gan Israel

41. UCSF Cancer Genetics and Prevention Program; San Francisco USA

42. Department of Clinical Genetics; Maastricht University Medical Center; Maastricht The Netherlands

43. Unité de Prévention et d'Epidémiologie Génétique; Centre Léon Bérard, 28 rue Laënnec; Lyon France

44. Department of Medicine, Abramson Cancer Center; Perelman School of Medicine at the University of Pennsylvania; Philadelphia USA

45. Department of Clinical Genetics; Royal Devon & Exeter Hospital; Exeter UK

46. Service de Génétique; Institut Curie, 26 rue d'Ulm; Paris France

47. Department of Medicine; Huntsman Cancer Institute; Salt Lake City USA

48. Molecular Oncology Laboratory; Hospital Clinico San Carlos; Instituto de Investigación Sanitaria San Carlos (IdISSC); Centro Investigación Biomédica en Red de Cáncer (CIBERONC); Madrid Spain

49. Institute of Human Genetics; University Hospital of Schleswig-Holstein; Kiel Germany

50. Section of Molecular Genetics, Dept. of Laboratory Medicine; University Hospital of Pisa; Pisa Italy

51. Research Division; Peter MacCallum Cancer Centre; Melbourne Australia

52. CRCHU de Quebec-oncologie, Centre des maladies du sein Deschênes-Fabia; Hôpital du Saint-Sacrement; Sainte-Foy Canada

53. Departments of Pediatrics and Medicine; Columbia University; New York USA

54. Center for Medical Genetics; Ghent University; Gent Belgium

55. Department of Clinical Genetics, Family Cancer Clinic; Erasmus University Medical Center; Rotterdam The Netherlands

56. Sheffield Clinical Genetics Service; Sheffield Children's Hospital; Sheffield UK

57. Department of Clinical Genetics; South Glasgow University Hospitals; Glasgow UK

58. Unité d'oncogénétique; ICO-Centre René Gauducheau; Saint Herblain France

59. Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Clinical and Molecular Genetics Area; Vall d'Hebron University Hospital; Barcelona Spain

60. Department of Population Sciences; Beckman Research Institute of City of Hope; Duarte USA

61. Department of Gynaecology and Obstetrics; Ludwig-Maximilian University; Munich Germany

62. Cáncer Hereditario, Instituto de Biología y Genética Molecular, IBGM; Universidad de Valladolid; Valladolid Spain

63. Institute of Human Genetics; University of Münster; Münster Germany

64. Nottingham Clinical Genetics Service; Nottingham University Hospitals NHS Trust; Nottingham UK

65. Oncogenetics Team; The Institute of Cancer Research and Royal Marsden NHS Foundation Trust; London UK

66. Department of Clinical Genetics; Lund University Hospital; Lund Sweden

67. Department of Oncology, Rigshospitalet; Copenhagen University Hospital; Copenhagen Denmark

68. Institute for Medical Informatics, Statistics and Epidemiology; University of Leipzig; Leipzig Germany

69. Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar; Technical University; Munich Germany

70. Genomic Medicine, Manchester Academic Health Sciences Centre, Division of Evolution and Genomic Sciences; University of Manchester, Central Manchester University Hospitals NHS Foundation Trust; Manchester UK

71. Centre de Lutte Contre le Cancer Georges François Leclerc, France and Genomic and Immunotherapy Medical Institute; Dijon University Hospital; Dijon France

72. Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Catalan Institute of Oncology-Bellvitge Biomedical Research Institute); Barcelona Spain

73. Laboratoire de Génétique Chromosomique; Hôtel Dieu Centre Hospitalier; Chambéry France

74. Department of Cancer Epidemiology and Genetics; Masaryk Memorial Cancer Institute; Brno Czech Republic

75. Columbus Cancer Council, Ohio State University; Columbus USA

76. Oncogenetics Department; Barretos Cancer Hospital; Barretos Brazil

77. UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research; Jonsson Comprehensive Cancer Center; Los Angeles USA

78. Cancer Risk and Prevention Clinic; Dana-Farber Cancer Institute; Boston USA

79. Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics; University of Würzburg, Germany; Würzburg

80. Department of Clinical Genetics; Copenhagen Denmark

81. Service Régional Oncogénétique Poitou-Charentes; Centre Hospitalier; Niort France

82. Department of Molecular Medicine; University La Sapienza, and Istituto Pasteur - Fondazione Cenci-Bolognetti; Rome Italy

83. Bâtiment Cheney D; Centre Léon Bérard; Lyon France

84. Ontario Cancer Genetics Network: Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Toronto Canada

85. Department of Pathology and Laboratory Medicine; University of Kansas Medical Center; Kansas City USA

86. Clinical Genetics Branch, DCEG, NCI; NIH; Bethesda USA

87. Department of Genetics and Pathology; Pomeranian Medical University; Szczecin Poland

88. Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty; University Hospital Cologne; Cologne Germany

89. Institute of Genetic Medicine; Centre for Life; Newcastle Upon Tyne Hospitals NHS Trust; Newcastle upon Tyne UK

90. Institute of Human Genetics; University Leipzig; Leipzig Germany

91. Family Cancer Clinic; Netherlands Cancer Institute; Amsterdam The Netherlands

92. Department of Gynaecology and Obstetrics; University Hospital Düsseldorf, Heinrich-Heine University; Düsseldorf Germany

93. N.N. Petrov Institute of Oncology; St. Petersburg Russia

94. Lombardi Comprehensive Cancer Center; Georgetown University; Washington USA

95. Clinical Genetics; Guy's and St. Thomas’ NHS Foundation Trust; London UK

96. Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona); Catalan Institute of Oncology; Girona Spain

97. Parkville Familial Cancer Centre; Peter MacCallum Cancer Centre; Melbourne Australia

98. Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine; Vilnius University Hospital Santariskiu Clinics; Vilnius Lithuania

99. Department of Clinical Genetics; Aarhus University Hospital; Aarhus N Denmark

100. Department of Epidemiology, Cancer Prevention Institute of California; Fremont USA

101. Department of Health Research and Policy (Epidemiology) and Stanford Cancer Institute; Stanford University School of Medicine; Stanford USA

102. Clinical Genetics Research Laboratory, Dept. of Medicine; Memorial Sloan-Kettering Cancer Center; New York USA

103. Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute; Cedars-Sinai Medical Center; Los Angeles USA

104. Department of Gynecology and Obstetrics; Medical Faculty and University Hospital Carl Gustav Carus; Dresden Germany

105. Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria; Australia and The Sir Peter MacCallum Department of Oncology University of Melbourne; Parkville Australia

106. Department of Surgery; Daerim St. Mary's Hospital; Seoul Korea

107. Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology); National Centre for Scientific Research “Demokritos”; Athens Greece

108. The Gyneco-Oncology Department; Chaim Sheba Medical Center; Ramat Gan Israel

109. Servicio de Genética-CIBERER U705; Hospital de la Santa Creu i Sant Pau; Barcelona Spain

110. The Feinstein Institute for Medical Research; Manhasset USA

111. Department of Surgery; Soonchunhyang University and Seoul Hospital; Seoul Korea

112. Inserm U900, Institut Curie; PSL Research University; Paris France

113. Department of Oncology Radiumhemmet and Institution of Oncology and Patology; Karolinska University Hospital and Karolinska Institutet; Solna Sweden

114. Department of Health Sciences Research; Mayo Clinic; Scottsdale USA

115. Oncogénétique; Institut Bergonié; Bordeaux France

116. Clinical Genetics Branch, DCEG, NCI, NIH; Bethesda USA

117. Department of Gynecological Oncology and Clinical Cancer Genetics Program; University Of Texas MD Anderson Cancer Center; Houston USA

118. Centre Antoine Lacassagne; Nice France

119. Laboratorio de Genética Molecular, Servicio de Genética; Hospital Universitario Cruces, BioCruces Health Research Institute; Barakaldo Spain

120. Department of Surgery; National Institute of Oncology; Budapest Hungary

121. Department of Clinical Genetics; VU University Medical Center; Amsterdam The Netherlands

122. Department of Human Genetics; Radboud University Medical Center; Nijmegen The Netherlands

123. Vilnius university Santariskiu hospital; National Center of Pathology; Vilnius Lithuania

124. NRG Oncology; Statistics and Data Management Center; Roswell Park Cancer Institute; Buffalo USA

125. Department of Cancer Prevention and Control; Roswell Park Cancer Institute; Buffalo USA

126. Department of Laboratory Medicine and Pathobiology; University of Toronto; Toronto Canada

127. Department of Obstetrics and Gynecology; University of Helsinki and Helsinki University Hospital; HUS Finland

128. Cancer Genetics Service; Division of Medical Oncology; National Cancer Centre Singapore; Bukit Merah Singapore

129. Institute of Medical Genetics and Applied Genomics; University of Tuebingen; Tuebingen Germany

130. Center for Genomic Medicine; Rigshospitalet; University of Copenhagen; Copenhagen Denmark

131. Cancer Genetics and Prevention Program; University of California San Francisco; San Francisco USA

132. Clinical Genetics Research Laboratory; Dept. of Medicine; Cancer Biology and Genetics; Memorial Sloan-Kettering Cancer Center; New York USA

133. Department of Clinical Genetics; Sahlgrenska University Hospital; Gothenburg Sweden

134. West Midlands Regional Genetics Service; Birmingham Women's Hospital Healthcare NHS Trust; Edgbaston UK

135. Human Genetics Group; Human Cancer Genetics Programme; Spanish National Cancer Research Centre (CNIO); Biomedical Network on Rare Diseases (CIBERER); Madrid Spain

136. Unit of Medical Genetics; Department of Biomedical; Experimental and Clinical Sciences; University of Florence; Florence Italy

137. Department of Medical Sciences; University of Turin; Turin Italy

138. Section of Molecular Diagnostics; Department of Biochemistry; Aalborg University Hospital; Aalborg Denmark

139. Department of Genetics; Portuguese Oncology Institute of Porto (IPO Porto); Porto Portugal

140. Biomedical Sciences Institute (ICBAS); University of Porto; Porto Portugal

141. IFOM; The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology; Milan Italy

142. Service de Génétique Clinique Chromosomique et Moléculaire; Hôpital Nord; St Etienne France

143. Unité d'Oncogénétique; CHU Arnaud de Villeneuve; Montpellier France

144. Unit of Molecular Bases of Genetic Risk and Genetic Testing; Department of Research; Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale Tumori (INT); Milan Italy

145. School of Women's and Children's Health; UNSW; Sydney Australia

146. The Kinghorn Cancer Centre; Garvan Institute of Medical Research; Sydney Australia

147. Department of Clinical Genetics; Karolinska University Hospital; Stockholm Sweden

148. Department of Basic Sciences; Shaukat Khanum Memorial Cancer Hospital and Research Centre; Lahore Pakistan

149. Clinical Genetics Services; Dept. of Medicine; Memorial Sloan-Kettering Cancer Center; New York USA

150. Division of Gynecologic Oncology; North Shore University Health System; University of Chicago; Evanston USA

151. All Wales Medical Genetics Services; University Hospital of Wales; Cardiff UK

152. Department of Gynecology; Vilnius University Hospital Santariskiu Clinics; Centre of Woman's Health and pathology; Vilnius Lithuania

153. Clinical Cancer Genetics Program; Division of Human Genetics; Department of Internal Medicine; The Comprehensive Cancer Center; The Ohio State University; Columbus USA

154. Department of Internal Medicine; Division of Oncology; University of Kansas Medical Center; Westwood USA

155. North East Thames Regional Genetics Service; Great Ormond Street Hospital for Children NHS Trust; London UK

156. Genomics Center; Centre Hospitalier Universitaire de Québec Research Center and Laval University; Quebec City Canada

157. Medical Genetics Unit; University of London; St George's UK

158. Département Oncologie Génétique; Prévention et Dépistage; Institut Paoli-Calmettes; Marseille Medical School-AM University; Marseille France

159. Genetic Epidemiology Laboratory; Department of Pathology; University of Melbourne; Parkville Australia

160. Institute of Cell and Molecular Pathology; Hannover Medical School; Hannover Germany

161. Institute of Human Genetics; University Hospital Heidelberg; Heidelberg Germany

162. National Human Genome Research Institute; National Institutes of Health; Bethesda USA

163. Department of Epidemiology; Columbia University; New York USA

164. Genetic Counseling Unit; Hereditary Cancer Program; IDIBELL (Bellvitge Biomedical Research Institute); Catalan Institute of Oncology, CIBERONC; Gran Via de l'Hospitalet; Barcelona Spain

165. Department of Health Sciences Research; Mayo Clinic; Rochester USA

166. Department of Medicine; Magee-Womens Hospital; University of Pittsburgh School of Medicine; Pittsburgh USA

167. Program in Cancer Genetics; Departments of Human Genetics and Oncology; McGill University; Montreal Canada

168. Division of Human Genetics; Departments of Internal Medicine and Cancer Biology and Genetics; Comprehensive Cancer Center; The Ohio State University; Columbus USA

169. Parkville Familial Cancer Centre; Royal Melbourne Hospital; Melbourne Australia

170. Department of Medical Oncology; Beth Israel Deaconess Medical Center; Massachusetts USA

171. Department of Clinical Genetics; Leiden University Medical Center; Leiden The Netherlands

172. Department of Genetics; University Medical Center; Groningen University; Groningen The Netherlands

173. Department of Medical Genetics; University Medical Center; Utrecht The Netherlands

174. Unit of Hereditary Cancer; Department of Epidemiology, Prevention and Special Functions; IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro; Genoa Italy

175. Institute of Human Genetics; Campus Virchov Klinikum; Berlin Germany

176. Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS, Santiago de Compostela; Spain

177. Departamento de Investigacion y de Tumores Mamarios del; Instituto Nacional de Cancerologia; Mexico City Mexico

178. Centro de Cancer de Mama del Hospital Zambrano Hellion; Tecnologico de Monterrey; San Pedro Garza Garcia Mexico

179. Department of Oncology; Karolinska University Hospital; Stockholm Sweden

180. Oxford Regional Genetics Service; Churchill Hospital; Oxford UK

181. Department of Gynaecology and Obstetrics; University Hospital; Ulm Germany

182. Institute of Human Genetics; Regensburg University; Regensburg Germany

183. Institute of Oncology; Rivka Ziv Medical Center; Zefat Israel

184. Magee-Womens Hospital; University of Pittsburgh School of Medicine; Pittsburgh USA

185. Center for Medical Genetics; North Shore University Health System; Evanston USA

186. Medical Director, Center for Medical Genetics, NorthShore University HealthSystem, Clinical Assistant Professor of Medicine; University of Chicago Pritzker School of Medicine; Evanston USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Genetics (clinical),Genetics

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