Mutational spectrum in a worldwide study of 29,700 families withBRCA1orBRCA2mutations

Author:

Rebbeck Timothy R.1,Friebel Tara M.1,Friedman Eitan2,Hamann Ute3,Huo Dezheng4,Kwong Ava5,Olah Edith6,Olopade Olufunmilayo I.4,Solano Angela R.7,Teo Soo-Hwang8,Thomassen Mads9,Weitzel Jeffrey N.10,Chan TL11,Couch Fergus J.12,Goldgar David E.13,Kruse Torben A.9,Palmero Edenir Inêz14,Park Sue Kyung151617,Torres Diana318,van Rensburg Elizabeth J.19,McGuffog Lesley20,Parsons Michael T.21,Leslie Goska20,Aalfs Cora M.22,Abugattas Julio23,Adlard Julian24,Agata Simona25,Aittomäki Kristiina26,Andrews Lesley27,Andrulis Irene L.2829,Arason Adalgeir30,Arnold Norbert31,Arun Banu K.32,Asseryanis Ella33,Auerbach Leo33,Azzollini Jacopo34,Balmaña Judith35,Barile Monica36,Barkardottir Rosa B.30,Barrowdale Daniel20,Benitez Javier3738,Berger Andreas39,Berger Raanan40,Blanco Amie M.41,Blazer Kathleen R.10,Blok Marinus J.42,Bonadona Valérie43,Bonanni Bernardo36,Bradbury Angela R.44,Brewer Carole45,Buecher Bruno46,Buys Saundra S.47,Caldes Trinidad48,Caliebe Almuth49,Caligo Maria A.50,Campbell Ian51,Caputo Sandrine M.46,Chiquette Jocelyne52,Chung Wendy K.53,Claes Kathleen B.M.54,Collée J. Margriet55,Cook Jackie56,Davidson Rosemarie57,de la Hoya Miguel48,De Leeneer Kim54,de Pauw Antoine46,Delnatte Capucine58,Diez Orland59,Ding Yuan Chun60,Ditsch Nina61,Domchek Susan M.44,Dorfling Cecilia M.19,Velazquez Carolina62,Dworniczak Bernd63,Eason Jacqueline64,Easton Douglas F.20,Eeles Ros65,Ehrencrona Hans66,Ejlertsen Bent67,Engel Christoph68,Engert Stefanie69,Evans D. Gareth70,Faivre Laurence71,Feliubadaló Lidia72,Ferrer Sandra Fert73,Foretova Lenka74,Fowler Jeffrey75,Frost Debra20,Galvão Henrique C. R.76,Ganz Patricia A.77,Garber Judy78,Gauthier-Villars Marion46,Gehrig Andrea79,Gerdes Anne-Marie80,Gesta Paul81,Giannini Giuseppe82,Giraud Sophie83,Glendon Gord84,Godwin Andrew K.85,Greene Mark H.86,Gronwald Jacek87,Gutierrez-Barrera Angelica32,Hahnen Eric88,Hauke Jan88,Henderson Alex89,Hentschel Julia90,Hogervorst Frans B.L.91,Honisch Ellen92,Imyanitov Evgeny N.93,Isaacs Claudine94,Izatt Louise95,Izquierdo Angel96,Jakubowska Anna87,James Paul97,Janavicius Ramunas98,Jensen Uffe Birk99,John Esther M.100101,Vijai Joseph102,Kaczmarek Katarzyna87,Karlan Beth Y.103,Kast Karin104,Investigators KConFab105,Kim Sung-Won106,Konstantopoulou Irene107,Korach Jacob108,Laitman Yael2,Lasa Adriana109,Lasset Christine43,Lázaro Conxi72,Lee Annette110,Lee Min Hyuk111,Lester Jenny103,Lesueur Fabienne112,Liljegren Annelie113,Lindor Noralane M.114,Longy Michel115,Loud Jennifer T.116,Lu Karen H.117,Lubinski Jan87,Machackova Eva74,Manoukian Siranoush34,Mari Véronique118,Martínez-Bouzas Cristina119,Matrai Zoltan120,Mebirouk Noura112,Meijers-Heijboer Hanne E.J.121,Meindl Alfons69,Mensenkamp Arjen R.122,Mickys Ugnius123,Miller Austin124,Montagna Marco25,Moysich Kirsten B.125,Mulligan Anna Marie126,Musinsky Jacob102,Neuhausen Susan L.60,Nevanlinna Heli127,Ngeow Joanne128,Nguyen Huu Phuc129,Niederacher Dieter92,Nielsen Henriette Roed9,Nielsen Finn Cilius130,Nussbaum Robert L.131,Offit Kenneth132,Öfverholm Anna133,Ong Kai-ren134,Osorio Ana135,Papi Laura136,Papp Janos6,Pasini Barbara137,Pedersen Inge Sokilde138,Peixoto Ana139140,Peruga Nina87,Peterlongo Paolo141,Pohl Esther88,Pradhan Nisha102,Prajzendanc Karolina87,Prieur Fabienne142,Pujol Pascal143,Radice Paolo144,Ramus Susan J.145146,Rantala Johanna147,Rashid Muhammad Usman3148,Rhiem Kerstin88,Robson Mark149,Rodriguez Gustavo C.150,Rogers Mark T.151,Rudaitis Vilius152,Schmidt Ane Y.130,Schmutzler Rita Katharina88,Senter Leigha153,Shah Payal D.44,Sharma Priyanka154,Side Lucy E.155,Simard Jacques156,Singer Christian F.33,Skytte Anne-Bine99,Slavin Thomas P.10,Snape Katie157,Sobol Hagay158,Southey Melissa158159,Steele Linda60,Steinemann Doris160,Sukiennicki Grzegorz87,Sutter Christian161,Szabo Csilla I.162,Tan Yen Y.39,Teixeira Manuel R.139140,Terry Mary Beth163,Teulé Alex164,Thomas Abigail165,Thull Darcy L.166,Tischkowitz Marc167,Tognazzo Silvia25,Toland Amanda Ewart168,Topka Sabine102,Trainer Alison H169,Tung Nadine170,van Asperen Christi J.171,van der Hout Annemieke H.172,van der Kolk Lizet E.91,van der Luijt Rob B.173,Van Heetvelde Mattias54,Varesco Liliana174,Varon-Mateeva Raymonda175,Vega Ana176,Villarreal-Garza Cynthia177178,von Wachenfeldt Anna179,Walker Lisa180,Wang-Gohrke Shan181,Wappenschmidt Barbara88,Weber Bernhard H. F.182,Yannoukakos Drakoulis107,Yoon Sook-Yee8,Zanzottera Cristina34,Zidan Jamal183,Zorn Kristin K.184,Hutten Selkirk Christina G.185,Hulick Peter J.186,Chenevix-Trench Georgia21,Spurdle Amanda B.21,Antoniou Antonis C.20,Nathanson Katherine L.44, , ,

Affiliation:

1. Harvard TH Chan School of Public Health and Dana Farber Cancer Institute; Boston USA

2. The Susanne Levy Gertner Oncogenetics Unit; Institute of Human Genetics; Chaim Sheba Medical Center, Ramat Gan 52621, and the Sackler School of Medicine; Tel-Aviv University; Tel-Aviv Israel

3. Molecular Genetics of Breast Cancer; German Cancer Research Center (DKFZ); Heidelberg Germany

4. Center for Clinical Cancer Genetics and Global Health; University of Chicago; Chicago USA

5. The Hong Kong Hereditary Breast Cancer Family Registry; Cancer Genetics Center; Hong Kong Sanatorium and Hospital; Hong Kong China

6. Department of Molecular Genetics; National Institute of Oncology; Budapest Hungary

7. INBIOMED; Faculty of Medicine, University of Buenos Aires/CONICET and CEMIC, Department of Clinical Chemistry; Medical Direction; Buenos Aires Argentina

8. Cancer Research Initiatives Foundation; Sime Darby Medical Centre; Subang Jaya Malaysia

9. Department of Clinical Genetics; Odense University Hospital; Odense Denmark

10. Division of Clinical Cancer Genomics; City of Hope Cancer Center; California USA

11. Division of Molecular Pathology; Department of Pathology; Hong Kong Sanatorium & Hospital; Happy Valley Hong Kong

12. Department of Laboratory Medicine and Pathology; and Health Sciences Research; Rochester USA

13. Department of Dermatology; University of Utah School of Medicine; Salt Lake City USA

14. Molecular Oncology Research Center; Barretos Cancer Hospital; São Paulo Brazil

15. Department of Preventive Medicine; Seoul National University College of Medicine; Seoul Korea

16. Department of Biomedical Science; Seoul National University Graduate School; Seoul Korea

17. Cancer Research Center; Seoul National University; Seoul Korea

18. Institute of Human Genetics; Pontificia Universidad Javeriana; Colombia

19. Cancer Genetics Laboratory, Department of Genetics; University of Pretoria; South Africa

20. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care; University of Cambridge; Cambridge UK

21. Genetics and Computational Biology Department; QIMR Berghofer Medical Research Institute; Brisbane Australia

22. Department of Clinical Genetics; Academic Medical Center; Amsterdam The Netherlands

23. City of Hope Clinical Cancer Genomics Community Research Network; Duarte USA

24. Yorkshire Regional Genetics Service; Chapel Allerton Hospital; Leeds UK

25. Immunology and Molecular Oncology Unit; Veneto Institute of Oncology IOV - IRCCS; Padua Italy

26. Department of Clinical Genetics; Helsinki University Hospital; Helsinki Finland

27. Hereditary Cancer Clinic; Prince of Wales Hospital; Randwick Australia

28. Lunenfeld-Tanenbaum Research Institute; Toronto Canada

29. Department of Molecular Genetics; University of Toronto; Toronto Canada

30. Laboratory of Cell Biology, Department of Pathology, hus 9, Landspitali-LSH v/Hringbraut, 101 Reykjavik, Iceland and BMC (Biomedical Centre), Faculty of Medicine; University of Iceland; Reykjavik Iceland

31. Department of Gynaecology & Oncology; Medical University of Vienna; Austria

32. Department of Breast Medical Oncology and Clinical Cancer Genetics Program; University Of Texas MD Anderson Cancer Center; Houston USA

33. Dept of OB/GYN and Comprehensive Cancer Center; Medical University of Vienna; Vienna Austria

34. Unit of Medical Genetics, Department of Medical Oncology and Hematology; Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Instituto Nazionale Tumori (INT); Milan Italy

35. Department of Medical Oncology; Vall d'Hebron University Hospital; Barcelona Spain

36. Division of Cancer Prevention and Genetics; Istituto Europeo di Oncologia (IEO); Milan Italy

37. Human Genetics Group and Genotyping Unit (CEGEN), Human Cancer Genetics Programme; Spanish National Cancer Research Centre (CNIO); Madrid Spain

38. Biomedical Network on Rare Diseases (CIBERER); Madrid Spain

39. Dept of OB/GYN, Comprehensive Cancer Center; Medical University of Vienna; Vienna Austria

40. The Institute of Oncology; Chaim Sheba Medical Center; Ramat Gan Israel

41. UCSF Cancer Genetics and Prevention Program; San Francisco USA

42. Department of Clinical Genetics; Maastricht University Medical Center; Maastricht The Netherlands

43. Unité de Prévention et d'Epidémiologie Génétique; Centre Léon Bérard, 28 rue Laënnec; Lyon France

44. Department of Medicine, Abramson Cancer Center; Perelman School of Medicine at the University of Pennsylvania; Philadelphia USA

45. Department of Clinical Genetics; Royal Devon & Exeter Hospital; Exeter UK

46. Service de Génétique; Institut Curie, 26 rue d'Ulm; Paris France

47. Department of Medicine; Huntsman Cancer Institute; Salt Lake City USA

48. Molecular Oncology Laboratory; Hospital Clinico San Carlos; Instituto de Investigación Sanitaria San Carlos (IdISSC); Centro Investigación Biomédica en Red de Cáncer (CIBERONC); Madrid Spain

49. Institute of Human Genetics; University Hospital of Schleswig-Holstein; Kiel Germany

50. Section of Molecular Genetics, Dept. of Laboratory Medicine; University Hospital of Pisa; Pisa Italy

51. Research Division; Peter MacCallum Cancer Centre; Melbourne Australia

52. CRCHU de Quebec-oncologie, Centre des maladies du sein Deschênes-Fabia; Hôpital du Saint-Sacrement; Sainte-Foy Canada

53. Departments of Pediatrics and Medicine; Columbia University; New York USA

54. Center for Medical Genetics; Ghent University; Gent Belgium

55. Department of Clinical Genetics, Family Cancer Clinic; Erasmus University Medical Center; Rotterdam The Netherlands

56. Sheffield Clinical Genetics Service; Sheffield Children's Hospital; Sheffield UK

57. Department of Clinical Genetics; South Glasgow University Hospitals; Glasgow UK

58. Unité d'oncogénétique; ICO-Centre René Gauducheau; Saint Herblain France

59. Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Clinical and Molecular Genetics Area; Vall d'Hebron University Hospital; Barcelona Spain

60. Department of Population Sciences; Beckman Research Institute of City of Hope; Duarte USA

61. Department of Gynaecology and Obstetrics; Ludwig-Maximilian University; Munich Germany

62. Cáncer Hereditario, Instituto de Biología y Genética Molecular, IBGM; Universidad de Valladolid; Valladolid Spain

63. Institute of Human Genetics; University of Münster; Münster Germany

64. Nottingham Clinical Genetics Service; Nottingham University Hospitals NHS Trust; Nottingham UK

65. Oncogenetics Team; The Institute of Cancer Research and Royal Marsden NHS Foundation Trust; London UK

66. Department of Clinical Genetics; Lund University Hospital; Lund Sweden

67. Department of Oncology, Rigshospitalet; Copenhagen University Hospital; Copenhagen Denmark

68. Institute for Medical Informatics, Statistics and Epidemiology; University of Leipzig; Leipzig Germany

69. Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar; Technical University; Munich Germany

70. Genomic Medicine, Manchester Academic Health Sciences Centre, Division of Evolution and Genomic Sciences; University of Manchester, Central Manchester University Hospitals NHS Foundation Trust; Manchester UK

71. Centre de Lutte Contre le Cancer Georges François Leclerc, France and Genomic and Immunotherapy Medical Institute; Dijon University Hospital; Dijon France

72. Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Catalan Institute of Oncology-Bellvitge Biomedical Research Institute); Barcelona Spain

73. Laboratoire de Génétique Chromosomique; Hôtel Dieu Centre Hospitalier; Chambéry France

74. Department of Cancer Epidemiology and Genetics; Masaryk Memorial Cancer Institute; Brno Czech Republic

75. Columbus Cancer Council, Ohio State University; Columbus USA

76. Oncogenetics Department; Barretos Cancer Hospital; Barretos Brazil

77. UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research; Jonsson Comprehensive Cancer Center; Los Angeles USA

78. Cancer Risk and Prevention Clinic; Dana-Farber Cancer Institute; Boston USA

79. Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics; University of Würzburg, Germany; Würzburg

80. Department of Clinical Genetics; Copenhagen Denmark

81. Service Régional Oncogénétique Poitou-Charentes; Centre Hospitalier; Niort France

82. Department of Molecular Medicine; University La Sapienza, and Istituto Pasteur - Fondazione Cenci-Bolognetti; Rome Italy

83. Bâtiment Cheney D; Centre Léon Bérard; Lyon France

84. Ontario Cancer Genetics Network: Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Toronto Canada

85. Department of Pathology and Laboratory Medicine; University of Kansas Medical Center; Kansas City USA

86. Clinical Genetics Branch, DCEG, NCI; NIH; Bethesda USA

87. Department of Genetics and Pathology; Pomeranian Medical University; Szczecin Poland

88. Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty; University Hospital Cologne; Cologne Germany

89. Institute of Genetic Medicine; Centre for Life; Newcastle Upon Tyne Hospitals NHS Trust; Newcastle upon Tyne UK

90. Institute of Human Genetics; University Leipzig; Leipzig Germany

91. Family Cancer Clinic; Netherlands Cancer Institute; Amsterdam The Netherlands

92. Department of Gynaecology and Obstetrics; University Hospital Düsseldorf, Heinrich-Heine University; Düsseldorf Germany

93. N.N. Petrov Institute of Oncology; St. Petersburg Russia

94. Lombardi Comprehensive Cancer Center; Georgetown University; Washington USA

95. Clinical Genetics; Guy's and St. Thomas’ NHS Foundation Trust; London UK

96. Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona); Catalan Institute of Oncology; Girona Spain

97. Parkville Familial Cancer Centre; Peter MacCallum Cancer Centre; Melbourne Australia

98. Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine; Vilnius University Hospital Santariskiu Clinics; Vilnius Lithuania

99. Department of Clinical Genetics; Aarhus University Hospital; Aarhus N Denmark

100. Department of Epidemiology, Cancer Prevention Institute of California; Fremont USA

101. Department of Health Research and Policy (Epidemiology) and Stanford Cancer Institute; Stanford University School of Medicine; Stanford USA

102. Clinical Genetics Research Laboratory, Dept. of Medicine; Memorial Sloan-Kettering Cancer Center; New York USA

103. Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute; Cedars-Sinai Medical Center; Los Angeles USA

104. Department of Gynecology and Obstetrics; Medical Faculty and University Hospital Carl Gustav Carus; Dresden Germany

105. Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria; Australia and The Sir Peter MacCallum Department of Oncology University of Melbourne; Parkville Australia

106. Department of Surgery; Daerim St. Mary's Hospital; Seoul Korea

107. Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology); National Centre for Scientific Research “Demokritos”; Athens Greece

108. The Gyneco-Oncology Department; Chaim Sheba Medical Center; Ramat Gan Israel

109. Servicio de Genética-CIBERER U705; Hospital de la Santa Creu i Sant Pau; Barcelona Spain

110. The Feinstein Institute for Medical Research; Manhasset USA

111. Department of Surgery; Soonchunhyang University and Seoul Hospital; Seoul Korea

112. Inserm U900, Institut Curie; PSL Research University; Paris France

113. Department of Oncology Radiumhemmet and Institution of Oncology and Patology; Karolinska University Hospital and Karolinska Institutet; Solna Sweden

114. Department of Health Sciences Research; Mayo Clinic; Scottsdale USA

115. Oncogénétique; Institut Bergonié; Bordeaux France

116. Clinical Genetics Branch, DCEG, NCI, NIH; Bethesda USA

117. Department of Gynecological Oncology and Clinical Cancer Genetics Program; University Of Texas MD Anderson Cancer Center; Houston USA

118. Centre Antoine Lacassagne; Nice France

119. Laboratorio de Genética Molecular, Servicio de Genética; Hospital Universitario Cruces, BioCruces Health Research Institute; Barakaldo Spain

120. Department of Surgery; National Institute of Oncology; Budapest Hungary

121. Department of Clinical Genetics; VU University Medical Center; Amsterdam The Netherlands

122. Department of Human Genetics; Radboud University Medical Center; Nijmegen The Netherlands

123. Vilnius university Santariskiu hospital; National Center of Pathology; Vilnius Lithuania

124. NRG Oncology; Statistics and Data Management Center; Roswell Park Cancer Institute; Buffalo USA

125. Department of Cancer Prevention and Control; Roswell Park Cancer Institute; Buffalo USA

126. Department of Laboratory Medicine and Pathobiology; University of Toronto; Toronto Canada

127. Department of Obstetrics and Gynecology; University of Helsinki and Helsinki University Hospital; HUS Finland

128. Cancer Genetics Service; Division of Medical Oncology; National Cancer Centre Singapore; Bukit Merah Singapore

129. Institute of Medical Genetics and Applied Genomics; University of Tuebingen; Tuebingen Germany

130. Center for Genomic Medicine; Rigshospitalet; University of Copenhagen; Copenhagen Denmark

131. Cancer Genetics and Prevention Program; University of California San Francisco; San Francisco USA

132. Clinical Genetics Research Laboratory; Dept. of Medicine; Cancer Biology and Genetics; Memorial Sloan-Kettering Cancer Center; New York USA

133. Department of Clinical Genetics; Sahlgrenska University Hospital; Gothenburg Sweden

134. West Midlands Regional Genetics Service; Birmingham Women's Hospital Healthcare NHS Trust; Edgbaston UK

135. Human Genetics Group; Human Cancer Genetics Programme; Spanish National Cancer Research Centre (CNIO); Biomedical Network on Rare Diseases (CIBERER); Madrid Spain

136. Unit of Medical Genetics; Department of Biomedical; Experimental and Clinical Sciences; University of Florence; Florence Italy

137. Department of Medical Sciences; University of Turin; Turin Italy

138. Section of Molecular Diagnostics; Department of Biochemistry; Aalborg University Hospital; Aalborg Denmark

139. Department of Genetics; Portuguese Oncology Institute of Porto (IPO Porto); Porto Portugal

140. Biomedical Sciences Institute (ICBAS); University of Porto; Porto Portugal

141. IFOM; The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology; Milan Italy

142. Service de Génétique Clinique Chromosomique et Moléculaire; Hôpital Nord; St Etienne France

143. Unité d'Oncogénétique; CHU Arnaud de Villeneuve; Montpellier France

144. Unit of Molecular Bases of Genetic Risk and Genetic Testing; Department of Research; Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale Tumori (INT); Milan Italy

145. School of Women's and Children's Health; UNSW; Sydney Australia

146. The Kinghorn Cancer Centre; Garvan Institute of Medical Research; Sydney Australia

147. Department of Clinical Genetics; Karolinska University Hospital; Stockholm Sweden

148. Department of Basic Sciences; Shaukat Khanum Memorial Cancer Hospital and Research Centre; Lahore Pakistan

149. Clinical Genetics Services; Dept. of Medicine; Memorial Sloan-Kettering Cancer Center; New York USA

150. Division of Gynecologic Oncology; North Shore University Health System; University of Chicago; Evanston USA

151. All Wales Medical Genetics Services; University Hospital of Wales; Cardiff UK

152. Department of Gynecology; Vilnius University Hospital Santariskiu Clinics; Centre of Woman's Health and pathology; Vilnius Lithuania

153. Clinical Cancer Genetics Program; Division of Human Genetics; Department of Internal Medicine; The Comprehensive Cancer Center; The Ohio State University; Columbus USA

154. Department of Internal Medicine; Division of Oncology; University of Kansas Medical Center; Westwood USA

155. North East Thames Regional Genetics Service; Great Ormond Street Hospital for Children NHS Trust; London UK

156. Genomics Center; Centre Hospitalier Universitaire de Québec Research Center and Laval University; Quebec City Canada

157. Medical Genetics Unit; University of London; St George's UK

158. Département Oncologie Génétique; Prévention et Dépistage; Institut Paoli-Calmettes; Marseille Medical School-AM University; Marseille France

159. Genetic Epidemiology Laboratory; Department of Pathology; University of Melbourne; Parkville Australia

160. Institute of Cell and Molecular Pathology; Hannover Medical School; Hannover Germany

161. Institute of Human Genetics; University Hospital Heidelberg; Heidelberg Germany

162. National Human Genome Research Institute; National Institutes of Health; Bethesda USA

163. Department of Epidemiology; Columbia University; New York USA

164. Genetic Counseling Unit; Hereditary Cancer Program; IDIBELL (Bellvitge Biomedical Research Institute); Catalan Institute of Oncology, CIBERONC; Gran Via de l'Hospitalet; Barcelona Spain

165. Department of Health Sciences Research; Mayo Clinic; Rochester USA

166. Department of Medicine; Magee-Womens Hospital; University of Pittsburgh School of Medicine; Pittsburgh USA

167. Program in Cancer Genetics; Departments of Human Genetics and Oncology; McGill University; Montreal Canada

168. Division of Human Genetics; Departments of Internal Medicine and Cancer Biology and Genetics; Comprehensive Cancer Center; The Ohio State University; Columbus USA

169. Parkville Familial Cancer Centre; Royal Melbourne Hospital; Melbourne Australia

170. Department of Medical Oncology; Beth Israel Deaconess Medical Center; Massachusetts USA

171. Department of Clinical Genetics; Leiden University Medical Center; Leiden The Netherlands

172. Department of Genetics; University Medical Center; Groningen University; Groningen The Netherlands

173. Department of Medical Genetics; University Medical Center; Utrecht The Netherlands

174. Unit of Hereditary Cancer; Department of Epidemiology, Prevention and Special Functions; IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro; Genoa Italy

175. Institute of Human Genetics; Campus Virchov Klinikum; Berlin Germany

176. Fundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica-USC, CIBERER, IDIS, Santiago de Compostela; Spain

177. Departamento de Investigacion y de Tumores Mamarios del; Instituto Nacional de Cancerologia; Mexico City Mexico

178. Centro de Cancer de Mama del Hospital Zambrano Hellion; Tecnologico de Monterrey; San Pedro Garza Garcia Mexico

179. Department of Oncology; Karolinska University Hospital; Stockholm Sweden

180. Oxford Regional Genetics Service; Churchill Hospital; Oxford UK

181. Department of Gynaecology and Obstetrics; University Hospital; Ulm Germany

182. Institute of Human Genetics; Regensburg University; Regensburg Germany

183. Institute of Oncology; Rivka Ziv Medical Center; Zefat Israel

184. Magee-Womens Hospital; University of Pittsburgh School of Medicine; Pittsburgh USA

185. Center for Medical Genetics; North Shore University Health System; Evanston USA

186. Medical Director, Center for Medical Genetics, NorthShore University HealthSystem, Clinical Assistant Professor of Medicine; University of Chicago Pritzker School of Medicine; Evanston USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Genetics (clinical),Genetics

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