Sensitivity to the non-COX inhibiting celecoxib derivative, OSU03012, is p21WAF1/CIP1dependent

Author:

Ding Haiming,Han Chunhua,Guo Dongmei,Wang Dasheng,Duan Wenrui,Chen Ching-Shih,D'Ambrosio Steven M.

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference47 articles.

1. Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours;Kucab;Breast Cancer Res,2005

2. Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor;Tseng;Mol Pharmacol,2006

3. Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival;Caron;Mol Cancer Ther,2005

4. Cytotoxicity of a non-cyclooxygenase-2 inhibitory derivative of celecoxib in non-small-cell lung cancer A549 cells;Tong;Lung Cancer,2006

5. A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth;Li;J Gastrointest Surg,2006

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