Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity-Reference-Cited by-同舟云学术

Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity

Published:2020-09-08 Issue:2 Volume:109 Page:433-442
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Beaudoin James J.¹^ORCID,Brock William J.²^ORCID,Watkins Paul B.¹^ORCID,Brouwer Kim L. R.¹^ORCID

Affiliation:

1. Division of Pharmacotherapy and Experimental Therapeutics UNC Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina USA

2. Brock Scientific Consulting LLC Montgomery Village Maryland USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2007

Reference35 articles.

1. Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

2. Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database

3. Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease

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