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Effect of lamotrigine on epilepsy-induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole-kindled animal model

  • Published:2016-12-01 Issue:2 Volume:71 Page:e21945
  • ISSN:0887-4476
  • Container-title:Synapse
  • language:en
  • Short-container-title:Synapse

Author:

Zhang Bing1,Zhang Jia-Wei1,Wang Wei-Ping1,Dong Rui-Fang2,Tian Shuang3,Zhang Chao3

Affiliation:

1. Key Laboratory of Neurology of Hebei Province; The Second Hospital of Hebei Medical University; Shijiazhuang 050000 China

2. Department of Neurology; Cangzhou central Hospital; Cangzhou 061000 China

3. Department of Neurology; the First Hospital of Shijiazhuang; Shijiazhuang 050000 China

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

Reference24 articles.

1. New antiepileptic drugs;Bazil;Neurologist,2002

2. The effects of antiepileptic drugs on cognitive functional magnetic resonance imaging;Beltramini;Quantitative Imaging in Medicine and Surgery,2015

3. Lamotrigine (BW430C), a potential anticonvulsant. Effects on the central nervous system in comparison with phenytoin and diazepam;Cohen;British Journal of Clinical Pharmacology,1985

4. Lamotrigine decreased hippocampal damage and improved vascular risk markers in a rat model of pentylenetetrazole induced kindling seizure;Haggag;Korean Journal of Physiology and Pharmacology,2014

5. Certain secondary antiepileptic drugs can rescue hippocampal injury following a critical growth period despite poor anticonvulsant activity and cognitive deficits;Halbsgut;Epilepsy Behaviour,2013
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