Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB‐4en‐PICA, MDMB‐4en‐PINACA, ADB‐4en‐PINACA, and MMB‐4CN‐BUTINACA using a combination of binding and different CB 1 receptor activation assays: Part I—Synthesis, analytical characterization, and binding affinity for human CB 1 receptors

Author:

Pike Edward123,Grafinger Katharina Elisabeth45ORCID,Cannaert Annelies5ORCID,Ametovski Adam12,Luo Jia Lin16,Sparkes Eric12,Cairns Elizabeth A.16ORCID,Ellison Ross7,Gerona Roy7,Stove Christophe P.5ORCID,Auwärter Volker4ORCID,Banister Samuel D.12ORCID

Affiliation:

1. The Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre The University of Sydney Camperdown New South Wales Australia

2. School of Chemistry The University of Sydney Sydney New South Wales Australia

3. Department of Chemistry University of York York UK

4. Institute of Forensic Medicine, Forensic Toxicology, Medical Center—University of Freiburg, Faculty of Medicine University of Freiburg Freiburg Germany

5. Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences Ghent University Ghent Belgium

6. School of Psychology The University of Sydney Sydney New South Wales Australia

7. Clinical Toxicology and Environmental Biomonitoring Laboratory, School of Medicine University of California San Francisco California USA

Funder

National Health and Medical Research Council

Fonds Wetenschappelijk Onderzoek

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Wiley

Subject

Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry

Reference51 articles.

1. ‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs?

2. World Drug Report 2020

3. United Nations Office on Drugs and Crime.The challenge of new psychoactive substances: a report from the Global SMART Programme 2013.https://www.unodc.org/documents/scientific/NPS_Report.pdf(accessed 16 December 2020).

4. Application of an activity‐based receptor bioassay to investigate the in vitro activity of selected indole‐ and indazole‐3‐carboxamide‐based synthetic cannabinoids at CB1 and CB2 receptors

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