An allosteric antibody to the leptin receptor reduces body weight and reverses the diabetic phenotype in the Lepob/Lepobmouse
Author:
Affiliation:
1. Preclinical Development, XOMA Corporation; Berkeley California USA
2. Discovery Research, XOMA Corporation; Berkeley California USA
Publisher
Wiley
Subject
Nutrition and Dietetics,Endocrinology,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)
Reference40 articles.
1. Leptin and OB-R: body weight regulation by a cytokine receptor;White;Cytokine Growth Factor Rev,1996
2. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice;Chen;Cell,1996
3. Leptin and the central nervous system control of glucose metabolism;Morton;Physiol Rev,2011
4. Leptin signaling in the central nervous system and the periphery;Bjorbaek;Recent Prog Hormone Res,2004
5. Leptin receptor signaling: pathways to leptin resistance;Wauman;Front Biosci,2012
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