In Vitro Assays to Predict In Vivo Interactions of P-Glycoprotein with Drugs
Author:
Affiliation:
1. Office of Clinical Pharmacology; Center for Drug Evaluation and Research, Food and Drug Administration; Silver Spring MD
Publisher
John Wiley & Sons, Inc.
Reference44 articles.
1. Transporters in drug disposition;Kim;Curr Opin Drug Discov Dev,2000
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3. Refining the in vitro and in vivo critical parameters for P-glycoprotein, [I]/IC50 and [I2]/IC50, that allow for the exclusion of drug candidates from clinical digoxin interaction studies;Cook;Mol Pharm,2010
4. Drug-drug interactions mediated through P-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug;Fenner;Clin Pharmacol Ther,2009
5. Food and Drug Administration Draft Guidance. Guidance for Industry: Drug Interaction Studies-Study Design, Data Analysis, and Implications for Dosing and Labeling 2012 http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm064982.htm
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