Adverse Outcome Pathways can drive non‐animal approaches for safety assessment

Author:

Burden Natalie1,Sewell Fiona1,Andersen Melvin E.2,Boobis Alan3,Chipman J. Kevin4,Cronin Mark T. D.5,Hutchinson Thomas H.6,Kimber Ian7,Whelan Maurice8

Affiliation:

1. NC3Rs Gibbs Building, 215 Euston Road London NW1 2BE UK

2. Hamner Institutes for Health Sciences Research Triangle Park North Carolina 27709 USA

3. Imperial College London, Hammersmith Campus Du Cane Road London W12 0NN UK

4. University of Birmingham School of Biosciences Edgbaston Birmingham B15 2TT UK

5. Liverpool John Moores University School of Pharmacy and Biomolecular Sciences Byrom Street Liverpool L3 3AF UK

6. Plymouth University School of Life Sciences Drake Circus Plymouth PL4 8AA UK

7. University of Manchester Oxford Road Manchester M13 9PT UK

8. European Commission Joint Research Centre EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) 20127 Ispra (VA) Italy

Publisher

Wiley

Subject

Toxicology

Reference9 articles.

1. New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis

2. OECD.2012.The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins. Part 1: Scientific Evidence. Series on Testing and Assessment No. 168.

3. OECD.2013.Guidance Document on Developing and Assessing Adverse Outcome Pathways Series on Testing and Assessment No. 184 (ENV/JM/MONO(2013)6).www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=env/jm/mono%282013%296&doclanguage=en.

4. OECD.2014.Users’ Handbook Supplement to the Guidance Document for Developing and Assessing AOPs.https://aopkb.org/common/AOP_Handbook.pdf.

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