The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis

Author:

Carbone Marco12,Sharp Stephen J.3,Flack Steve1,Paximadas Dimitrios1,Spiess Kelly1,Adgey Carolyn4,Griffiths Laura5,Lim Reyna6,Trembling Paul7,Williamson Kate8,Wareham Nick J.3,Aldersley Mark9,Bathgate Andrew10,Burroughs Andrew K.11,Heneghan Michael A.12,Neuberger James M.6,Thorburn Douglas11,Hirschfield Gideon M.13,Cordell Heather J.14,Alexander Graeme J.2,Jones David E.J.5,Sandford Richard N.1,Mells George F.12,

Affiliation:

1. Academic Department of Medical Genetics, University of Cambridge; Cambridge United Kingdom

2. Division of Gastroenterology and Hepatology; Addenbrooke's Hospital; Cambridge United Kingdom

3. MRC Epidemiology Unit, University of Cambridge; Cambridge United Kingdom

4. Liver Unit, Royal Victoria Hospital; Belfast United Kingdom

5. Institute of Cellular Medicine, Newcastle University; Newcastle upon Tyne United Kingdom

6. Liver Unit, Queen Elizabeth Hospital; Birmingham United Kingdom

7. Liver Unit, Barts and the London NHS Trust; London United Kingdom

8. Translational Gastroenterology Unit, John Radcliffe Hospital; Oxford United Kingdom

9. Liver Unit, St James's University Hospital; Leeds United Kingdom

10. Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh; Edinburgh United Kingdom

11. Sheila Sherlock Liver Center, The Royal Free London NHS Foundation Trust; London United Kingdom

12. Institute of Liver Studies, King's College Hospital NHS Foundation Trust; London United Kingdom

13. Center for Liver Research and NIHR Biomedical Research Unit, University of Birmingham; Birmingham United Kingdom

14. Institute of Genetic Medicine, Newcastle University; Newcastle upon Tyne United Kingdom

Funder

Isaac Newton Trust, University of Cambridge

Addenbrooke's Charitable Trust (ACT), Cambridge University Hospitals NHS Foundation Trust

PBC Foundation; Intercept Pharmaceuticals, the Wellcome Trust

Medical Research Council (MRC)

MC is a Sheila Sherlock Fellow of the European Association for the Study of the Liver (EASL)

Sackler Trust at the University of Cambridge

National Institute for Health Research Rare Diseases (NIHT-RD) initiative

MRC stratified medicine award

NIHR Comprehensive Research Network (CRN)

Publisher

Wiley

Subject

Hepatology

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