A Phase II Trial of Lutikizumab, an Anti–Interleukin‐1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis-Reference-Cited by-同舟云学术

A Phase II Trial of Lutikizumab, an Anti–Interleukin‐1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis

Published:2019-06-07 Issue:7 Volume:71 Page:1056-1069
ISSN:2326-5191
Container-title:Arthritis & Rheumatology
language:en
Short-container-title:Arthritis Rheumatol

Author:

Fleischmann Roy M.¹^ORCID,Bliddal Henning²,Blanco Francisco J.³^ORCID,Schnitzer Thomas J.⁴,Peterfy Charles⁵,Chen Su⁶,Wang Li⁶,Feng Sheng⁶,Conaghan Philip G.⁷,Berenbaum Francis⁸,Pelletier Jean‐Pierre⁹,Martel‐Pelletier Johanne⁹,Vaeterlein Ole¹⁰,Kaeley Gurjit S.¹¹,Liu Wei⁶,Kosloski Matthew P.⁶,Levy Gwen⁶,Zhang Lanju⁶,Medema Jeroen K.⁶,Levesque Marc C.⁶

Affiliation:

1. University of Texas Southwestern Medical Center Dallas

2. Bispebjerg‐Frederiksberg Hospital and University of Copenhagen Copenhagen Denmark

3. Hospital Universitario A Coruña La Coruña Spain

4. Northwestern University Feinberg School of Medicine Chicago Illinois

5. Spire Sciences, Inc. Boca Raton Florida

6. AbbVie Inc. North Chicago Illinois

7. University of Leeds and NIHR Leeds Biomedical Research Centre Leeds UK

8. Sorbonne UniversitéINSERM, and AP‐HP Hospital Saint‐Antoine Paris France

9. Centre Hospitalier de l’Université de Montréal Montreal Quebec Canada

10. Bioclinica Hamburg Germany

11. University of Florida College of Medicine

Funder

AbbVie

Publisher

Wiley

Subject

Immunology,Rheumatology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.40840

Reference51 articles.

1. Centers for Disease Control and Prevention.Osteoarthritis (OA). URL:https://www.cdc.gov/arthritis/basics/osteoarthritis.htm.

2. Prevalence and most common causes of disability among adults—United States, 2005;Centers for Disease Control and Prevention;MMWR Morb Mortal Wkly Rep,2009

3. EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: Prevalence of inflammation in osteoarthritis

4. Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI

5. Synovitis in knee osteoarthritis: a precursor of disease?

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