LACC1: A critical involvement in macrophage immunometabolism

Abstract

AbstractLaccase domain‐containing 1 (LACC1) protein is an enzyme highly expressed in inflammatory macrophages, and studies have shown that it has a key role in diseases such as inflammatory bowel disease, arthritis, and microbial infections. Therefore, in this review, we focus on LACC1‐mediated catalysis. In detail, LACC1 converts l‐CITrulline (l‐CIT) to l‐ORNithine (l‐ORN) and isocyanic acid in mice and humans and acts as a bridge between proinflammatory nitric oxide synthase (NOS2) and polyamine immunometabolism, thus exerting anti‐inflammatory and antibacterial effects. Considering the actions of LACC1, targeting LACC1 may be a potent therapeutic avenue for inflammation‐related diseases and microbial infection diseases.