High Levels of DEK Autoantibodies in Sera of Patients With Polyarticular Juvenile Idiopathic Arthritis and With Early Disease Flares Following Cessation of Anti-Tumor Necrosis Factor Therapy

Author:

Mor-Vaknin Nirit1,Rivas Miguel1ORCID,Legendre Maureen1,Mohan Smriti1,Yuanfan Ye1,Mau Theresa1,Johnson Anne2,Huang Bin3,Zhao Lili1,Kimura Yukiko4,Spalding Steven J.5,Morris Paula W.6,Gottlieb Beth S.7,Onel Karen4,Olson Judyann C.8,Edelheit Barbara S.9,Shishov Michael10,Jung Lawrence K.11,Cassidy Elaine A.12,Prahalad Sampath13,Passo Murray H.14,Beukelman Timothy15,Mehta Jay16,Giannini Edward H.2,Adams Barbara S.1,Lovell Daniel J.2,Markovitz David M.1

Affiliation:

1. University of Michigan; Ann Arbor

2. Cincinnati Children's Hospital Medical Center; Cincinnati Ohio

3. Cincinnati Children's Hospital Medical Center and University of Cincinnati School of Medicine; Cincinnati Ohio

4. Joseph M. Sanzari Children's Hospital; Hackensack University Medical Center; Hackensack New Jersey

5. The Cleveland Clinic; Cleveland Ohio

6. University of Arkansas for Medical Science; Little Rock

7. Cohen Children's Medical Center, Northwell Health; Hofstra Norwell School of Medicine; Hempstead New York

8. Medical College of Wisconsin; Milwaukee

9. Connecticut Children's Medical Center; Hartford

10. Phoenix Children's Hospital; Phoenix Arizona

11. Children's National Medical Center; Washington DC

12. Children's Hospital of Pittsburgh; Pittsburgh Pennsylvania

13. Emory University School of Medicine; Atlanta Georgia

14. Medical University of South Carolina; Charleston

15. University of Alabama at Birmingham

16. Children's Hospital at Montefiore/Albert Einstein College of Medicine; Bronx New York

Funder

National Institutes of Health

Center for Scientific Review

Rheumatology Research Foundation

Publisher

Wiley

Subject

Immunology,Rheumatology,Immunology and Allergy

Reference38 articles.

1. Juvenile idiopathic arthritis;Prakken;Lancet,2011

2. Juvenile idiopathic arthritis;Ravelli;Lancet,2007

3. DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen;Mor-Vaknin;Arthritis Rheum,2011

4. A novel autoantibody to the putative oncoprotein DEK in pauciarticular onset juvenile rheumatoid arthritis;Szer;J Rheumatol,1994

5. Antinuclear antibody profile in juvenile rheumatoid arthritis;Szer;J Rheumatol,1991

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