The association of umbilical cord blood oxidative stress with maternal iron deficiency anemia: A tertiary center experience

Author:

Farisoğullari Nihat1ORCID,Tanaçan Atakan1ORCID,Sakcak Bedri1ORCID,Denizli Ramazan1ORCID,Özdemir Eda Üreyen2ORCID,Elmas Burak2ORCID,Canpolat Fuat Emre3ORCID,Neşelioğlu Salim4ORCID,Erel Özcan4ORCID,Şahin Dilek1ORCID

Affiliation:

1. Division of Perinatology, Department of Obstetrics and Gynecology Turkish Ministry of Health Ankara City Hospital Ankara Turkey

2. Department of Gynecology and Obstetrics Turkish Ministry of Health Ankara City Hospital Ankara Turkey

3. Department of Neonatology Turkish Ministry of Health Ankara City Hospital Ankara Turkey

4. Department of Biochemistry Turkish Ministry of Health Ankara City Hospital Ankara Turkey

Abstract

AbstractObjectiveTo compare the levels of oxidative stress markers in the umbilical cord blood between pregnant women diagnosed with iron deficiency anemia (IDA) and low‐risk controls.MethodsThe sample consisted of 131 patients, including 55 pregnant women with IDA and 76 controls with similar demographic characteristics. Participants were selected from patients delivered at ≥37 weeks. We compared the two groups in terms of the native thiol, total thiol, disulfide, and ischemia‐modified albumin (IMA) levels measured in pregnant women's umbilical cord venous blood.ResultsThe native thiol and total thiol values were statistically significantly lower in the anemia group, and the disulfide and IMA values were statistically significantly higher in the IDA group (P < 0.001). Perinatal outcomes were similar between the groups.ConclusionIn the present study, pregnant women with IDA had lower native and total thiol values and higher disulfide and IMA values in umbilical cord blood. Iron deficiency anemia in pregnancy may be a potential cause of increased oxidative stress.

Publisher

Wiley

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