Development of a multivariable risk model integrating urinary cell DNA methylation and cell‐free RNA data for the detection of significant prostate cancer

Author:

Connell Shea P.1ORCID,O'Reilly Eve23,Tuzova Alexandra23,Webb Martyn1ORCID,Hurst Rachel1,Mills  Robert4,Zhao Fang5,Bapat Bharati5,Cooper Colin S.1,Perry Antoinette S.23,Clark Jeremy1,Brewer Daniel S.16ORCID

Affiliation:

1. Norwich Medical SchoolUniversity of East AngliaNorwich Research Park Norwich UK

2. School of Biology and Environmental ScienceUniversity College DublinDublin Ireland

3. Cancer Biology and Therapeutics Laboratory, Conway InstituteUniversity CollegeDublin Ireland

4. Department of UrologyNorfolk and Norwich University Hospitals NHS Foundation Trust Norfolk UK

5. Division of Urology, University Health NetworkUniversity of TorontoToronto Ontario Canada

6. Science DivisionThe Earlham InstituteNorwich Research Park Norwich Norfolk UK

Publisher

Wiley

Subject

Urology,Oncology

Reference45 articles.

1. Cancer Research UK.Prostate cancer incidence statistics.2019.http://www.cancerresearchuk.org/health‐professional/cancer‐statistics/statistics‐by‐cancer‐type/prostate‐cancer/incidence. Accessed June 29 2019.

2. Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline. Part I: Risk Stratification, Shared Decision Making, and Care Options

3. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part II: Treatment of Relapsing, Metastatic, and Castration-Resistant Prostate Cancer

4. National Institute for Health and Care Excellence (NICE). Prostate cancer: diagnosis and management. 2019.https://www.nice.org.uk/guidance/indevelopment/gid‐ng10057. Accessed July 4 2019.

5. Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality

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