Epidermal growth factor receptor signaling in precancerous keratinocytes promotes neighboring head and neck cancer squamous cell carcinoma cancer stem cell‐like properties and phosphoinositide 3‐kinase inhibitor insensitivity

Author:

Nguyen Khoa A.1,Keith Madison J.1,Keysar Stephen B.2,Hall Spencer C.1,Bimali Anamol1,Jimeno Antonio2,Wang Xiao‐Jing13,Young Christian D.1ORCID

Affiliation:

1. Department of Pathology University of Colorado Anschutz Medical Campus Aurora Colorado USA

2. Division of Medical Oncology, Department of Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA

3. Veterans Affairs Medical Center, VA Eastern Colorado Health Care System Aurora Colorado USA

Funder

U.S. Department of Veterans Affairs

Cancer League of Colorado

Cancer Center, University of Colorado

American Cancer Society

National Institutes of Health

Publisher

Wiley

Subject

Cancer Research,Molecular Biology

Reference60 articles.

1. Head and neck squamous cell carcinoma

2. Genetic progression model for head and neck cancer: implications for field cancerization;Califano J;Cancer Res,1996

3. The molecular biology of head and neck cancer

4. Oral field cancerization: an update on current concepts

5. Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications;Tabor MP;Clin Cancer Res,2001

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