Obesity is associated with acute kidney injury in ST‐segment‐elevation myocardial infarction undergoing percutaneous coronary intervention: A national representative cohort study

Author:

Ye Congyan1ORCID,Ma Xueping123,Shi Bo1ORCID,Yan Rui1,Fu Shizhe1ORCID,Wang Kairu1,Jia Shaobin123,Yan Ru123,Cong Guangzhi123

Affiliation:

1. Institute of Medical Sciences General Hospital of Ningxia Medical University Yinchuan China

2. Institute of Cardiovascular Medicine General Hospital of Ningxia Medical University Yinchuan China

3. Department of Cardiology, General Hospital of Ningxia Medical University Ningxia Medical University Yinchuan China

Abstract

AbstractBackgroundAcute kidney injury (AKI) is a frequent and potentially life‐threatening complication after percutaneous coronary intervention (PCI) in patients with ST‐segment‐elevation myocardial infarction (STEMI). However, the relationship between obesity and the risk of AKI in this specific patient population has not been previously examined.MethodsWe queried the National Inpatient Sample (2016–2019) using ICD‐10 codes to obtain a sample of adults with STEMI undergoing PCI. All patients were further subcategorized into obese and nonobese cohorts. The primary outcome was the incidence of AKI. Multivariate regression analysis was performed to assess the impact of obesity on AKI. The consistency of this correlation between subgroups was investigated using subgroup analysis and interaction testing.ResultsA total of 62,599 (weighted national estimate of 529,016) patients were identified, of which 9.80% (n = 6137) had AKI. Obesity comprised 19.78% (n = 1214) of the AKI cohort. Obese patients were on average younger, male, white, and had more comorbidities. Additionally, there was a significant positive association between obesity and AKI incidence (adjusted odds ratio [aOR]: 1.24, 95% confidence interval [CI]: 1.15–1.34), which was more pronounced in female patients (aOR: 1.56, 95% CI: 1.33–1.82, p < 0.001, p‐interaction = 0.008). The AKI incidence in these patients increased steadily during the 4‐year study period, and it was consistently higher in obese patients than in nonobese patients (p‐trend < 0.001 for all).ConclusionsObesity was independently associated with a greater risk of AKI among adults with STEMI undergoing PCI, particularly in female patients.

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3