Amplification and over-expression ofMAP3K3gene in human breast cancer promotes formation and survival of breast cancer cells

Author:

Fan Yihui12,Ge Ningling123,Wang Xiaosong45,Sun Wenjing12,Mao Renfang6,Bu Wen4,Creighton Chad J5,Zheng Pingju4,Vasudevan Sanjeev7,An Lei6,Yang Jinshu8,Zhao Yi-Jue12,Zhang Huiyuan9,Li Xiao-Nan12,Rao Pulivarthi H12,Leung Eastwood12,Lu Yong-Jie8,Gray Joe W10,Schiff Rachel4,Hilsenbeck Susan G45,Osborne C Kent45,Yang Jianhua125,Zhang Hong69

Affiliation:

1. Texas Children's Cancer Center; Baylor College of Medicine; Houston TX USA

2. Department of Pediatrics; Baylor College of Medicine; Houston TX USA

3. Liver Cancer Institute, Zhongshan Hospital; Fudan University; Shanghai People's Republic of China

4. Lester and Sue Smith Breast Center; Baylor College of Medicine; Houston TX USA

5. Dan L Duncan Cancer Center; Baylor College of Medicine; Houston TX USA

6. Department of Pathology; Baylor College of Medicine; Houston TX USA

7. Michael E DeBakey Department of Surgery; Baylor College of Medicine; Houston TX USA

8. Institute of Cancer, BLSMD; Queen Mary University of London; UK

9. Department of Pathology; MD Anderson Cancer Center; Houston TX 77030 USA

10. Department of Biomedical Engineering; Oregon Health and Science University; Portland OR USA

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference29 articles.

1. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene;Slamon;Science,1987

2. Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells;Ong;Proc Natl Acad Sci USA,2011

3. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23;Li;Nat Genet,2002

4. Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization;Kallioniemi;Proc Natl Acad Sci USA,1994

5. Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer;Isola;Am J Pathol,1995

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