Ubiquitin-independent, Proteasome-mediated targeted degradation of KRAS in pancreatic adenocarcinoma cells using an engineered ornithine decarboxylase/antizyme system

Author:

Ma Yihui1ORCID,Xu Jingjing1,Huang Pei1,Bai Xue1,Gao Hanqing1

Affiliation:

1. Department of Pathology; Zhengzhou University; 1st Affiliated Hospital, Zhengzhou China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Genetics,Molecular Biology,Biochemistry

Reference40 articles.

1. K-ras as a target for cancer therapy;Friday;Biochim. Biophys. Acta.,2005

2. KRAS alleles: the devil is in the detail;Haigis;Trends Cancer,2017

3. Mutant KRAS, chromosomal instability and prognosis in colorectal cancer;Castagnola;Biochim. Biophys. Acta,2005

4. Genetics and biology of pancreatic ductal adenocarcinoma;Ying;Genes Dev.,2016

5. K-Ras and its inhibitors towards personalized cancer treatment: pharmacological and structural perspectives;Asati;Eur. J. Med. Chem.,2017

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1. Expanding the ubiquitin code in pancreatic cancer;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2024-01

2. The Core Autophagy Protein ATG5 Regulates KRAS Degradation via the Ubiquitin-Proteasome Pathway;Biology Bulletin;2023-12

3. Regulation of large and small G proteins by ubiquitination;Journal of Biological Chemistry;2019-12

4. Issue Highlights;IUBMB Life;2018-12-19

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