Leveraging flow mechanics to determine critical process and scaling parameters in a continuous viral inactivation reactor-Reference-Cited by-同舟云学术

Leveraging flow mechanics to determine critical process and scaling parameters in a continuous viral inactivation reactor

Published:2019-11-19 Issue:3 Volume:117 Page:637-645
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnology and Bioengineering

Author:

Brown Matthew R.¹^ORCID,Orozco Raquel¹,Coffman Jon¹

Affiliation:

1. Bioprocess Engineering, Process ScienceBoehringer IngelheimFremont California

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27223

Reference15 articles.

1. Laminar-turbulent transition in Taylor-Dean flow

2. Impact of Dean vortices on the integrity testing of a continuous viral inactivation reactor;Amarikwa L.;Biotechnology Journal,2018

3. ASTM(2012).E2888‐12: Standard Practice for Process for Inactivation of Rodent Retrovirus by pH. West Conshohocken PA: ASTM International.http://www.astm.org

4. Bracketed generic inactivation of rodent retroviruses by low pH treatment for monoclonal antibodies and recombinant proteins

5. Characterization of operating parameters for XMuLV inactivation by low pH treatment

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