Histologic characterization of primary ciliary dyskinesia chronic rhinosinusitis

Author:

Kim Sulgi1ORCID,Li Lang2,Lin Feng‐Chang2,Stack Taylor1ORCID,Lamb Meredith M.1ORCID,Mohammad Ibtisam1,Norris Meghan1,Klatt‐Cromwell Cristine1,Thorp Brian D.1,Ebert Charles S.1,Masters Daniel3,Senior Brent A.1ORCID,Askin Frederic B.3,Kimple Adam J.1ORCID

Affiliation:

1. Department of Otolaryngology Head & Neck Surgery, University of North Carolina Chapel Hill North Carolina USA

2. Department of Biostatistics, Gillings School of Global Public Health Chapel Hill North Carolina USA

3. Department of Pathology and Laboratory Medicine, University of North Carolina Chapel Hill North Carolina USA

Abstract

Key points We present the largest cohort of structured histopathology reports on primary ciliary dyskinesia‐related chronic rhinosinusitis (PCD‐CRS). Despite endoscopic differences, PCD‐CRS and cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) had similar structured histopathology reports. Compared to healthy patients and those with idiopathic chronic rhinosinusitis without nasal polyps, patients with PCD‐CRS had an increased neutrophil count.

Funder

National Science Foundation

Doris Duke Charitable Foundation

Publisher

Wiley

Subject

Otorhinolaryngology,Immunology and Allergy

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