Study design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER)-Reference-Cited by-全球学者库

Study design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER)

Published:2023-09-30 Issue: Volume: Page:
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Baker Laura D.¹²³,Snyder Heather M.⁴,Espeland Mark A.¹²,Whitmer Rachel A.⁵,Kivipelto Miia⁶⁷⁸⁹,Woolard Nancy¹,Katula Jeffrey¹⁰,Papp Kathryn V.¹¹¹²¹³,Ventrelle Jennifer¹⁴,Graef Sarah¹⁴,Hill Marcus A.¹,Rushing Scott²,Spell Julia²,Lovato Laura²,Felton Deborah²,Williams Benjamin J.³,Ghadimi Nouran Mina¹,Raman Rema¹⁵,Ngandu Tiia⁶¹⁶,Solomon Alina⁶⁸⁹¹⁷,Wilmoth Sharon¹,Cleveland Maryjo L.¹,Williamson Jeff D.¹,Lambert Katherine L.¹⁸,Tomaszewski Farias Sarah¹⁹,Day Claire E.²⁰,Tangney Christy C.¹⁵,Gitelman Darren R.²¹,Matongo Olivia²²,Reynolds Terrianne²²,Pavlik Valory N.²³,Yu Melissa M.²³,Alexander Ashley S.²⁴,Elbein Richard²⁵,McDonald Ann Marie²⁵,Salloway Stephen²⁶,Wing Rena R.²⁷,Antkowiak Susan²⁸,Morris Martha Clare¹⁴,Carrillo Maria C.⁴,

Affiliation:

1. Wake Forest University School of Medicine Department of Internal Medicine Winston Salem North Carolina USA

2. Wake Forest University School of Medicine Division of Public Health Sciences Winston Salem North Carolina USA

3. Wake Forest University School of Medicine Department of Neurology Winston Salem North Carolina USA

4. Alzheimer's Association Chicago Illinois USA

5. University of California Davis Department of Public Health Sciences Sacramento California USA

6. Karolinska Institute, Division of Clinical Geriatrics Center for Alzheimer Research Stockholm Sweden

7. University of Eastern Finland Institute of Public Health and Clinical Nutrition Kuopio Finland

8. Imperial College London, School of Public Health Ageing Epidemiology Research Unit London UK

9. FINGERS Brain Health Institute Stockholm Sweden

10. Wake Forest University Department of Health and Exercise Science Winston Salem North Carolina USA

11. Brigham and Women's Hospital Department of Neurology Boston Massachusetts USA

12. Massachusetts General Hospital Department of Neurology Boston Massachusetts USA

13. Harvard Medical School Department of Neurology Boston Massachusetts USA

14. Rush University Medical Center, Departments of Clinical Nutrition and Family and Preventive Medicine Chicago Illinois USA

15. University of Southern California Alzheimer's Therapeutic Research Institute San Diego California USA

16. Finnish Institute for Health and Welfare Department of Public Health and Welfare Helsinki Finland

17. University of Eastern Finland Institute of Clinical Medicine/Neurology Kuopio Finland

18. Alzheimer's Association Western Carolina Chapter Charlotte North Carolina USA

19. University of California Davis Department of Neurology Sacramento California USA

20. Alzheimer's Association Northern California Northern Nevada Chapter San Jose California USA

21. Advocate Health Care Department of Behavioral Neurology Downers Grove Illinois USA

22. Alzheimer's Association Illinois Chapter Chicago Illinois USA

23. Baylor College of Medicine Department of Neurology Houston Texas USA

24. Kelsey Research Foundation Houston Texas USA

25. Alzheimer's Association Houston & Southeast Texas Chapter Houston Texas USA

26. Butler Hospital, Memory and Aging Program and Warren Alpert Medical School of Brown University Providence Rhode Island USA

27. Brown University, Department of Psychiatry and Human Behavior School of Medicine Providence Rhode Island USA

28. Alzheimer's Association Rhode Island Chapter Providence Rhode Island USA

Abstract

AbstractINTRODUCTIONThe U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER) is conducted to confirm and expand the results of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in Americans.METHODSU.S. POINTER was planned as a 2‐year randomized controlled trial of two lifestyle interventions in 2000 older adults at risk for dementia due to well‐established factors. The primary outcome is a global cognition composite that permits harmonization with FINGER.RESULTSU.S. POINTER is centrally coordinated and conducted at five clinical sites (ClinicalTrials.gov: NCT03688126). Outcomes assessments are completed at baseline and every 6 months. Both interventions focus on exercise, diet, cognitive/social stimulation, and cardiovascular health, but differ in intensity and accountability. The study partners with a worldwide network of similar trials for harmonization of methods and data sharing.DISCUSSIONU.S. POINTER is testing a potentially sustainable intervention to support brain health and Alzheimer's prevention for Americans. Impact is strengthened by the targeted participant diversity and expanded scientific scope through ancillary studies.

Funder

Alzheimer's Association

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Reference50 articles.

1. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

2. Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population‐based perspective

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