Affiliation:
1. Cancer Center, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China
Abstract
AbstractBackgroundA nomogram that incorporates tumor response at mid‐radiotherapy (mid‐RT) to predict the prognosis of locoregionally advanced nasopharyngeal carcinoma (LA‐NPC) has not been established.MethodsThis study retrospectively reviewed 583 patients with LA‐NPC who underwent magnetic resonance imaging scans at mid‐RT (the fourth week of RT) between 2015 and 2019.ResultsPrimary tumor (PT) response at mid‐RT was found to predict disease‐free survival (DFS) and overall survival (OS). Independent factors from multivariable analysis to predict DFS and OS were assembled into nomograms with (nomograms Amid‐RT and Bmid‐RT) or without (nomograms Abaseline and Bbaseline) PT response. Internal validation revealed good performance of these nomograms in discrimination: C‐statistics = 0.761 for nomogram Amid‐RT and 0.809 for nomogram Bmid‐RT, which showed better discrimination performance than (C‐statistics: 0.755) nomogram Abaseline and (C‐statistics: 0.798) nomogram Bbaseline (Z‐statistic = 2.476, p < 0.05; Z‐statistic = 1.971, p < 0.05).ConclusionThe nomograms based on PT response at mid‐RT showed favorable predictive accuracy for DFS and OS in patients with LA‐NPC.
Funder
National Natural Science Foundation of China