Impact of pretreatment body mass index on the survival of head and neck cancer patients-Reference-Cited by-同舟云学术

Impact of pretreatment body mass index on the survival of head and neck cancer patients

Published:2024-01-25 Issue:8 Volume:46 Page:1881-1892
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Yang Zheng¹²,Mansour Jobran²,Sun Peng²³^ORCID,Wei Peng⁴,Dahlstrom Kristina R.⁵,Zafereo Mark²,Li Guojun²⁶^ORCID,Gross Neil D.²^ORCID

Affiliation:

1. Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital, Capital Medical University; Key Laboratory of Otolaryngology Head and Neck Surgery of the Ministry of Education Beijing China

2. Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas USA

3. Department of Otolaryngology The First Affiliated Hospital of Soochow University Suzhou China

4. Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston Texas USA

5. Section of Epidemiology and Population Sciences Baylor College of Medicine Houston Texas USA

6. Division of Epidemiology The University of Texas School of Public Health Houston Texas USA

Abstract

AbstractBackgroundDifferences in pretreatment body mass index (BMI) have been associated with survival in squamous cell carcinoma of head and neck (SCCHN). We examined effects of BMI on survival in SCCHN patients after stratifying patients by tumor human papillomavirus (HPV) status and subsite.MethodsTotally 2204 SCCHN patients in a prospective study were included in this secondary analysis. Multivariable Cox models were used to evaluate associations between pretreatment BMI and overall survival, disease‐specific survival, and disease‐free survival.ResultsBMI was significantly higher among patients with HPV‐positive tumors than HPV‐negative tumors. BMI >25 kg/m2 was associated with improved survival, while BMI <18.5 kg/m2 was associated with reduced survival, particularly in patients with HPV‐positive oropharyngeal cancer tumors.ConclusionsThis exploratory analysis suggests that pretreatment BMI could be an independent prognostic factor of survival outcomes in SCCHN patients, particularly in patients with HPV‐positive oropharyngeal cancer tumors. Further prospective investigations are warranted.

Funder

National Institute of Environmental Health Sciences

Foundation for the National Institutes of Health

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27659

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