Species-related exposure of phase II metabolite gemfibrozil 1-O-β-glucuronide between human and mice: A net induction of mouse P450 activity was revealed

Author:

Luo Min1ORCID,Dai Manyun1,Lin Hante1,Xie Minzhu1,Lin Jiao1,Liu Aiming1,Yang Julin2

Affiliation:

1. Medical School of Ningbo University; Ningbo 315211 China

2. Ningbo College of Health Sciences; Ningbo 315100 China

Funder

Zhejiang Provincial Education Department

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference33 articles.

1. Gemfibrozil greatly increases plasma concentrations of cerivastatin;Backman;Clinical Pharmacology and Therapeutics,2002

2. Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach;Deguchi;Drug Metabolism & Disposition,2011

3. Comparative metabolism and disposition of gemfibrozil in male and female Sprague-Dawley rats and Syrian golden hamsters;Dix;Drug Metabolism and Disposition,1999

4. Drug-drug interaction between pitavastatin and various drugs via OATP1B1;Hirano;Drug Metabolism and Disposition,2006

5. Fibrates induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys;Hoivik;Carcinogenesis,2004

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