β ‐Glucuronidase‐ and OATP2B1 ‐mediated drug interaction of scutellarin in Dengzhan Xixin Injection: A formulation aspect-Reference-Cited by-同舟云学术

β ‐Glucuronidase‐ and OATP2B1 ‐mediated drug interaction of scutellarin in Dengzhan Xixin Injection: A formulation aspect

Published:2020-03-27 Issue:5 Volume:81 Page:609-619
ISSN:0272-4391
Container-title:Drug Development Research
language:en
Short-container-title:Drug Dev Res

Author:

Shi Jinxin¹²,Sun Chengpeng²,Huang Huilian³,Lin Wenhui¹,Gao Jian⁴,Lin Yanhe⁵,Zhang Zhanjun⁶,Huo Xiaokui²^ORCID,Tian Xiangge²,Yu Zhenlong²,Zhang Baojing²,Ma Xiaochi⁴⁶

Affiliation:

1. School of Chemical and Environmental EngineeringShanghai Institute of Technology Shanghai China

2. Institute of Integrative Medicine, College of PharmacyDalian Medical University Dalian China

3. Laboratory of Modern Preparation of TCM, Ministry of EducationJiangxi University of Traditional Chinese Medicine Nanchang China

4. Jiangsu Key Laboratory of New Drug Research and Clinical PharmacyXuzhou Medical University Xuzhou China

5. Yunnan Biovalley Pharmaceutical Company Kunming China

6. State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal University Beijing China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Drug Discovery

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ddr.21661

Reference33 articles.

1. Dengzhanhua preparations for acute cerebral infarction;Cao W.;Cochrane Database of Systematic Reviews,2008

2. Scutellarin and caffeic acid ester fraction, active components of Dengzhanxixin injection, upregulate neurotrophins synthesis and release in hypoxia/reoxygenation rat astrocytes

3. Reviewing the mechanisms of natural product-drug interactions involving efflux transporters and metabolic enzymes

4. Highly Selective NIR Probe for Intestinal β-Glucuronidase and High-Throughput Screening Inhibitors to Therapy Intestinal Damage

5. Mechanistic Studies on the Absorption and Disposition of Scutellarin in Humans: Selective OATP2B1-Mediated Hepatic Uptake Is a Likely Key Determinant for Its Unique Pharmacokinetic Characteristics

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