Affiliation:
1. David Greenfield Human Physiology Unit, School of Life Sciences University of Nottingham Nottingham UK
2. Radiology Department, College of Applied Medical Sciences Taif University Taif Saudi Arabia
3. Medical Physics and Clinical Engineering Nottingham University Hospitals NHS Trust Nottingham UK
Abstract
AbstractPurposeThere are many approaches to the quantitative BOLD (qBOLD) technique described in the literature, differing in pulse sequences, MRI parameters and data processing. Thus, in this review, we summarized the acquisition methods, approaches used for oxygenation quantification and clinical populations investigated.MethodsThree databases were systematically searched (Medline, Embase, and Web of Science) for published research that used qBOLD methods for quantification of oxygen metabolism. Data extraction and synthesis were performed by one author and reviewed by a second author.ResultsA total of 93 relevant papers were identified. Acquisition strategies were summarized, and oxygenation parameters were found to have been investigated in many pathologies such as steno‐occlusive diseases, stroke, glioma, and multiple sclerosis disease.ConclusionA summary of qBOLD approaches for oxygenation measurements and applications could help researchers to identify good practice and provide objective information to inform the development of future consensus recommendations.