Randomized pharmacokinetic and drug–drug interaction studies of ceftazidime, avibactam, and metronidazole in healthy subjects

Author:

Das Shampa1,Li Jianguo2,Armstrong Jon1,Learoyd Maria1,Edeki Timi3

Affiliation:

1. AstraZeneca Macclesfield United Kingdom

2. AstraZeneca Waltham Massachusetts

3. AstraZeneca Wilmington Delaware

Funder

AstraZeneca

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference24 articles.

1. BerkhoutJ MelchersMJ SeyedmousaviS LagardeCM SchuckV NicholsWW et al. (2013).Exposure response relationships of ceftazidime and avibactam in a neutropenic thigh model. 53rd Intersceince Conference on Antimicrobial Agents and Chemotherapy 2013 Denver CO USA.

2. 10 x '20 Progress--Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America

3. Randomized, placebo-controlled study to assess the impact on QT/QTc interval of supratherapeutic doses of ceftazidime-avibactam or ceftaroline fosamil-avibactam

4. Food and Drug Administration(2012).Guidance for industry: Drug Interaction Studies ‐ study design data analysis implications for dosing and labeling recommendations. Available athttp://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm292362.pdf. (accessed 12 June 2015).

5. Food and Drug Administration(2015).AVYCAZ (ceftazidime–avibactam) for injection for intravenous use: highlights of prescribing information. Available athttp://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206494s000lbl.pdf. (accessed 12 June 2015).

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