Utility of Normalized TdP Score System in Drug Proarrhythmic Potential Assessment: A Blinded in vitro Study of CiPA Drugs-Reference-Cited by-同舟云学术

Utility of Normalized TdP Score System in Drug Proarrhythmic Potential Assessment: A Blinded in vitro Study of CiPA Drugs

Published:2020-12-29 Issue:6 Volume:109 Page:1606-1617
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Liu Tengxian¹,Liu Jiang²,Lu Hua Rong³,Li Haiyan⁴,Gallacher David J.³,Chaudhary Khuram⁵,Wang Yaning²,Yan Gan‐Xin¹⁶

Affiliation:

1. Lankenau Institute for Medical Research Wynnewood Pennsylvania USA

2. Division of Pharmacometrics Office of Clinical Pharmacology Office of Translational Sciences Center for Drug Evaluation and Research US Food and Drug Administration Silver Spring Maryland USA

3. Janssen Pharmaceutica NV (J&J) Beerse Belgium

4. Department of Cardiology and Drug Clinical Trial Center Peking University Third Hospital Beijing China

5. GlaxoSmithKline Collegeville Pennsylvania USA

6. Sidney Kimmel Medical College at Thomas Jefferson University Philadelphia Pennsylvania USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2133

Reference41 articles.

1. 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary

2. Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: The role of experimental models

3. Drug-Induced Prolongation of the QT Interval

4. Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine

5. Mexiletine Prevents Recurrent Torsades de Pointes in Acquired Long QT Syndrome Refractory to Conventional Measures

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