Maternal cardiovascular function in midgestation is related to placental angiogenesis

Abstract

ABSTRACTObjectiveTo investigate whether angiogenic markers of placental function are associated with maternal cardiac function and hemodynamic responses at 19–23 weeks' gestation, controlling for maternal risk factors and pregnancy complications.MethodsThis was a prospective study of women with singleton pregnancy attending King's College Hospital, London, UK, for a routine hospital visit at 19–23 weeks' gestation. We recorded maternal characteristics and measured mean arterial pressure (MAP), maternal heart rate, serum placental growth factor (PlGF) and soluble fms‐like tyrosine kinase‐1 (sFlt‐1). We also performed maternal echocardiography to assess cardiac output and peripheral vascular resistance as well as indices of diastolic and systolic function.ResultsOur cohort included 4006 women. Lower PlGF values were significantly associated with higher MAP (P < 0.0001), lower maternal heart rate (P < 0.0001), lower mitral valve s′ mean velocity (P = 0.027) and higher left atrial area (P = 0.022) after adjustment for maternal characteristics and pregnancy complications. sFlt‐1 was associated positively with relative wall thickness (P = 0.012), whereas sFlt‐1/PlGF ratio was associated negatively with mitral valve A (P = 0.006) and positively with left atrial area (P = 0.015) and MAP (P = 0.004). The magnitude of these associations was similar in the subgroup of women without any risk factors based on their obstetric and medical history.ConclusionsA continuous association of moderate strength between angiogenic factors and subclinical maternal cardiac function alterations is present in midgestation, independently of pre‐existing maternal risk factors and pregnancy complications. Impaired placental function appears to be related to mild systolic and diastolic dysfunction and cardiac remodeling. © 2024 International Society of Ultrasound in Obstetrics and Gynecology.