Unraveling multilayered extracellular vesicles: Speculation on cause-Reference-Cited by-同舟云学术

Unraveling multilayered extracellular vesicles: Speculation on cause

Published:2023-02 Issue:2 Volume:12 Page:
ISSN:2001-3078
Container-title:Journal of Extracellular Vesicles
language:en
Short-container-title:J of Extracellular Vesicle

Author:

Broad Kelly¹²,Walker Sierra A.¹,Davidovich Irina³,Witwer Kenneth⁴⁵,Talmon Yeshayahu³,Wolfram Joy⁶⁷⁸^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology Department of Physiology and Biomedical Engineering Department of Transplantation Mayo Clinic Jacksonville Florida USA

2. Skaggs Graduate School of Chemical and Biological Sciences University of Florida Scripps Biomedical Research Jupiter Florida USA

3. Department of Chemical Engineering and the Russell Berrie Nanotechnology Institute (RBNI) Technion‐Israel Institute of Technology Haifa Israel

4. Department of Molecular and Comparative Pathobiology The Johns Hopkins University School of Medicine Baltimore Maryland USA

5. Department of Neurology The Johns Hopkins University School of Medicine Baltimore Maryland USA

6. School of Chemical Engineering The University of Queensland Brisbane Queensland Australia

7. Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane Queensland Australia

8. Department of Nanomedicine Houston Methodist Research Institute Houston Texas USA

Abstract

AbstractExtracellular vesicles (EVs) are cell‐released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. There has been minimal inquiry into differences between unilamellar and multilamellar EVs in terms of biogenesis mechanisms and functional effects. This commentary speculates on potential causes and roles of multilamellar EVs and serves as a call to action for the research community to unravel the complex layers of EVs.

Funder

University of Queensland

Israel Science Foundation

Publisher

Wiley

Subject

Cell Biology,Histology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jev2.12309

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