Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models

Author:

Bridgeman Victoria L1,Vermeulen Peter B12,Foo Shane1,Bilecz Agnes3,Daley Frances4,Kostaras Eleftherios1,Nathan Mark R1,Wan Elaine15,Frentzas Sophia15,Schweiger Thomas6,Hegedus Balazs78,Hoetzenecker Konrad6,Renyi-Vamos Ferenc9,Kuczynski Elizabeth A10,Vasudev Naveen S1511,Larkin James5,Gore Martin5,Dvorak Harold F12,Paku Sandor1314,Kerbel Robert S1015,Dome Balazs691617,Reynolds Andrew R1

Affiliation:

1. Tumour Biology Team, The Breast Cancer Now Toby Robins Research Centre; The Institute of Cancer Research; London UK

2. Translational Cancer Research Unit (TCRU); GZA Hospitals St Augustinus; Antwerp Belgium

3. 2nd Institute of Pathology; Semmelweis University; Budapest Hungary

4. Breast Cancer Now Histopathology Core Facility, The Royal Marsden; London UK

5. The Royal Marsden; London UK

6. Department of Thoracic Surgery; Medical University of Vienna; Vienna Austria

7. Department of Thoracic Surgery, Ruhrlandklinik Essen; University Hospital of University Duisburg-Essen; Germany

8. MTA-SE Molecular Oncology Research Group; Hungarian Academy of Sciences; Budapest Hungary

9. Department of Thoracic Surgery; Semmelweis University-National Institute of Oncology; Budapest Hungary

10. Department of Medical Biophysics; University of Toronto; Toronto Canada

11. Cancer Research UK Centre, Leeds Institute of Cancer and Pathology; St James's University Hospital; Leeds UK

12. Beth Israel Deaconess Medical Center; Boston MA USA

13. 1st Department of Pathology and Experimental Cancer Research; Semmelweis University; Budapest Hungary

14. Tumour Progression Research Group; Hungarian Academy of Sciences-Semmelweis University; Budapest Hungary

15. Biological Sciences Platform, Sunnybrook Research Institute; Toronto Canada

16. National Koranyi Institute of Pulmonology; Budapest Hungary

17. Department of Biomedical Imaging and Image-guided Therapy; Medical University of Vienna; Austria

Funder

Breakthrough Breast Cancer

NHS

Hungarian Scientific Research Fund

Semmelweis University Start-Up grant

ÖNB Jubiläumsfondsprojekt

Vienna Fund for Innovative Interdisciplinary Cancer Research

Publisher

Wiley

Subject

Pathology and Forensic Medicine

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