gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels

Author:

Larson Nicholas B.1,McDonnell Shannon1,Cannon Albright Lisa2,Teerlink Craig2,Stanford Janet3,Ostrander Elaine A.4,Isaacs William B.5,Xu Jianfeng6,Cooney Kathleen A.278,Lange Ethan9,Schleutker Johanna10,Carpten John D.11,Powell Isaac12,Bailey-Wilson Joan E.13,Cussenot Olivier14,Cancel-Tassin Geraldine14,Giles Graham G.1516,MacInnis Robert J.1516,Maier Christiane17,Whittemore Alice S.18,Hsieh Chih-Lin19,Wiklund Fredrik20,Catolona William J.21,Foulkes William2223,Mandal Diptasri24,Eeles Rosalind25,Kote-Jarai Zsofia2526,Ackerman Michael J.27,Olson Timothy M.27,Klein Christopher J.28,Thibodeau Stephen N.29,Schaid Daniel J.1

Affiliation:

1. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; Mayo Clinic; Rochester Minnesota United States of America

2. Department of Internal Medicine; University of Utah School of Medicine; Salt Lake City Utah United States of America

3. Fred Hutchinson Cancer Research Center; Seattle Washington United States of America

4. National Human Genome Research Institute; Bethesda Maryland United States of America

5. Brady Urological Institute, School of Medicine; Johns Hopkins University; Baltimore Maryland United States of America

6. NorthShore University HealthSystem Research Institute; Chicago Illinois United States of America

7. Department of Internal Medicine; University of Michigan Medical School; Ann Arbor Michigan United States of America

8. Department of Urology; University of Michigan Medical School; Ann Arbor Michigan United States of America

9. Department of Genetics; University of North Carolina; Chapel Hill North Carolina United States of America

10. Department of Medical Biochemistry and Genetics, Institute of Biomedicine; University of Turku; Turku Finland

11. Department of Translational Genomics; University of Southern California; Los Angeles California United States of America

12. Department of Urology; Wayne State University; Detroit Michigan United States of America

13. Statistical Genetics Section; National Human Genome Research Institute; Bethesda Maryland United States of America

14. CeRePP, Hopital Tenon; Paris France

15. Cancer Epidemiology Centre; Cancer Council Victoria; Melbourne Australia

16. Centre for Epidemiology and Biostatistics, School of Population and Global Health; University of Melbourne; Melbourne Australia

17. Department of Urology; University of Ulm; Ulm Germany

18. Department of Health Research and Policy; Stanford University; Stanford California United States of America

19. Department of Urology; University of Southern California; Los Angeles California United States of America

20. Department of Medical Epidemiology and Biostatistics; Karolinska Institutet; Stockholm Sweden

21. Department of Urology; Feinberg School of Medicine, Northwestern University; Chicago Illinois United States of America

22. Department of Oncology; Montreal General Hospital; Montreal Quebec Canada

23. Department of Human Genetics; Montreal General Hospital; Montreal Quebec Canada

24. Department of Genetics; LSU Health Sciences Center; New Orleans Louisiana United States of America

25. The Institute of Cancer Research; London UK

26. The Institute of Cancer Research and Royal Marsden NHS Foundation Trust; London

27. Department of Pediatric and Adolescent Medicine; Mayo Clinic; Rochester Minnesota United States of America

28. Department of Neurology; Mayo Clinic; Rochester Minnesota United States of America

29. Department of Laboratory Medicine/Pathology; Mayo Clinic; Rochester Minnesota United States of America

Funder

National Institutes of Health

National Cancer Institute

Mayo Clinic Center for Individualized Medicine

Publisher

Wiley

Subject

Genetics (clinical),Epidemiology

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