Development of a simple HPLC–MS/MS method to simultaneously determine teriflunomide and its metabolite in human plasma and urine: Application to clinical pharmacokinetic study of teriflunomide sodium and leflunomide-Reference-Cited by-同舟云学术

Development of a simple HPLC–MS/MS method to simultaneously determine teriflunomide and its metabolite in human plasma and urine: Application to clinical pharmacokinetic study of teriflunomide sodium and leflunomide

Published:2019-01-07 Issue:3 Volume:33 Page:e4420
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

Yao Xueting¹²^ORCID,Liu Yang¹²^ORCID,Song Ling¹²,Jiang Ji¹²,Xiao Fei³,Liu Dongyang¹²,Hu Pei¹²

Affiliation:

1. Clinical Pharmacology Research Center Phase I Unit, Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical Sciences Beijing China

2. Beijing Key Laboratory of Clinical PK and PD Investigation for Innovative Drugs Beijing China

3. Cinkate Pharmaceutical Intermediates (Shanghai) Co. Ltd China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.4420

Reference27 articles.

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2. The Efficacy and Safety of Leflunomide for the Treatment of Lupus Nephritis in Chinese Patients: Systematic Review and Meta-Analysis

3. Rapid determination of the active leflunomide metabolite A77 1726 in human plasma by high-performance liquid chromatography

4. China Food and Drug Administration(2015).Guideline on Bioanalytical Method Validation. China Pharmacopeia (version 2015).

5. Cinkate(2014).Teriflunomide sodium tablet investigator's brochure. Cinkate Pharmaceutical Intermediates (Shanghai) Co. Ltd.

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