Therapeutically targeting guanylate cyclase-C: computational modeling of plecanatide, a uroguanylin analog-Reference-Cited by-同舟云学术

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Therapeutically targeting guanylate cyclase-C: computational modeling of plecanatide, a uroguanylin analog

Published:2017-03-12 Issue:2 Volume:5 Page:e00295
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Brancale Andrea¹^ORCID,Shailubhai Kunwar²,Ferla Salvatore¹,Ricci Antonio¹,Bassetto Marcella¹,Jacob Gary S²

Affiliation:

1. School of Pharmacy and Pharmaceutical Sciences; Cardiff University; Cardiff United Kingdom

2. Synergy Pharmaceuticals; New York New York

Funder

Synergy Pharmaceuticals Inc

Life Science Research Network Wales

Welsh Government's Ser Cymru program

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference41 articles.

1. H++ 3.0: automating pK prediction and the preparation of bimolecular structures for atomistic molecular modeling and simulation;Anandakrishnan;Nucleic Acids Res,2012

2. Taking a lesson from microbial diarrheagenesis in the management of chronic constipation;Bharucha;Gastroenterology,2010

3. Guanylate cyclase-C receptor activation: unexpected biology;Brierley;Curr Opin Pharmacol,2012

4. Clarification of linaclotide pharmacology presented in a recent clinical study of plecanatide;Busby;Dig Dis Sci,2014

5. Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit;Busby;Eur J Pharmacol,2010

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