Pharmacokinetics of Diclofenac and Hydroxypropyl-β-Cyclodextrin (HPβCD) Following Administration of Injectable HPβCD-Diclofenac in Subjects With Mild to Moderate Renal Insufficiency or Mild Hepatic Impairment

Author:

Hamilton Douglas A.12,Ernst Cynthia C.1,Kramer William G.3,Madden Donna1,Lang Eric1,Liao Edward1,Lacouture Peter G.45,Ramaiya Atulkumar6,Carr Daniel B.17

Affiliation:

1. Javelin Pharmaceuticals; Cambridge MA USA (now Hospira, a Pfizer company, Lake Forest, IL, USA)

2. New Biology Ventures LLC; San Mateo CA USA

3. Kramer Consulting; LLC; North Potomac MD USA

4. Magidom Discovery; LLC; St. Augustine FL USA

5. Brown University School of Medicine; Providence RI USA

6. Hospira; a Pfizer company; Lake Forest IL USA

7. Department of Anesthesiology; Tufts Medical Center; Boston MA USA

Funder

Hospira, a Pfizer Company, Lake Forest, IL, USA

Javelin Pharmaceuticals, Inc., Cambridge, MA, USA (now Hospira, a Pfizer company)

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Reference40 articles.

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2. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment;Kehlet;Anesth Analg,1993

3. Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers;Hecken;J Clin Pharmacol,2000

4. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes;Kato;J Pharm Pharmacol,2001

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