Clinical Bioavailability of the Novel BACE1 Inhibitor Lanabecestat (AZD3293): Assessment of Tablet Formulations Versus an Oral Solution and the Impact of Gastric pH on Pharmacokinetics

Author:

Ye Naidong1,Monk Scott A.2,Daga Pankaj1,Bender David M.2,Rosen Laura B.1,Mullen Jamie1,Minkwitz Margaret C.1,Kugler Alan R.1

Affiliation:

1. AstraZeneca; Cambridge MA USA

2. Lilly Research Laboratories; Eli Lilly and Company; Indianapolis IN USA

Funder

AstraZeneca

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Reference33 articles.

1. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects;Vassar;J Neurochem.,2014

2. Advances in Alzheimer's disease drug development;Rafii;BMC Med.,2015

3. Dementia: a global health priority - highlights from an ADI and World Health Organization report;Wortmann;Alzheimers Res Ther.,2012

4. Prince M Guerchet M Prina M Alzheimer's Disease International: The Global Impact of Dementia 2013-2050 2013 https://www.alz.co.uk/research/GlobalImpactDementia2013.pdf

5. The Alzheimer's disease beta-secretase enzyme, BACE1;Cole;Mol Neurodegener,2007

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