The marginality principle revisited: Should “higher‐order” terms always be accompanied by “lower‐order” terms in regression analyses?

Author:

Morris Tim P.1ORCID,van Smeden Maarten2ORCID,Pham Tra My1ORCID

Affiliation:

1. MRC Clinical Trials Unit at UCL London UK

2. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht University Utrecht The Netherlands

Abstract

AbstractThe marginality principle guides analysts to avoid omitting lower‐order terms from models in which higher‐order terms are included as covariates. Lower‐order terms are viewed as “marginal” to higher‐order terms. We consider how this principle applies to three cases: regression models that may include the ratio of two measured variables; polynomial transformations of a measured variable; and factorial arrangements of defined interventions. For each case, we show that which terms or transformations are considered to be lower‐order, and therefore marginal, depends on the scale of measurement, which is frequently arbitrary. Understanding the implications of this point leads to an intuitive understanding of the curse of dimensionality. We conclude that the marginality principle may be useful to analysts in some specific cases but caution against invoking it as a context‐free recipe.

Funder

Medical Research Council

Publisher

Wiley

Subject

Statistics, Probability and Uncertainty,General Medicine,Statistics and Probability

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