Concise Review: Mesenchymal Stem Cells: From Roots to Boost

Author:

Andrzejewska Anna1,Lukomska Barbara1,Janowski Miroslaw123ORCID

Affiliation:

1. NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

2. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

3. Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA

Abstract

Abstract It was shown as long as half a century ago that bone marrow is a source of not only hematopoietic stem cells, but also stem cells of mesenchymal tissues. Then the term “mesenchymal stem cells” (MSCs) was coined in the early 1990s, and more than a decade later, the criteria for defining MSCs have been released by the International Society for Cellular Therapy. The easy derivation from a variety of fetal and adult tissues and undemanding cell culture conditions made MSCs an attractive research object. It was followed by the avalanche of reports from preclinical studies on potentially therapeutic properties of MSCs, such as immunomodulation, trophic support and capability for a spontaneous differentiation into connective tissue cells, and differentiation into the majority of cell types upon specific inductive conditions. Although ontogenesis, niche, and heterogeneity of MSCs are still under investigation, there is a rapid boost of attempts at clinical applications of MSCs, especially for a flood of civilization-driven conditions in so quickly aging societies, not only in the developed countries, but also in the populous developing world. The fields of regenerative medicine and oncology are particularly extensively addressed by MSC applications, in part due to the paucity of traditional therapeutic options for these highly demanding and costly conditions. There are currently almost 1,000 clinical trials registered worldwide at ClinicalTrials.gov, and it seems that we are starting to witness the snowball effect with MSCs becoming a powerful global industry; however, the spectacular effects of MSCs in the clinic still need to be shown. Stem Cells  2019;37:855–864

Funder

National Institutes of Health

NCR&D

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,Molecular Medicine

Reference97 articles.

1. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues;Friedenstein;Transplantation,1968

2. The development of fibroblast colonies in monolayer cultures of Guinea-pig bone marrow and spleen cells;Friedenstein;Cell Tissue Kinet,1970

3. Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo;Friedenstein;Transplantation,1974

4. Mesenchymal stem cells;Caplan;J Orthop Res,1991

5. Mesenchymal stem cells: Revisiting history, concepts, and assays;Bianco;Cell Stem Cell,2008

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