Affiliation:
1. Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon‐Based Functional Materials and Devices Soochow University Suzhou China
2. School of Optical and Electronic Information Suzhou City University Suzhou China
3. Department of Chemistry North Carolina State University Raleigh North Carolina USA
Abstract
AbstractMetal‐based nanomaterials have attracted broad attention recently due to their unique biological physical and chemical properties after entering tumor cells, namely biological effects. In particular, the abilities of Ca2+ to modulate T cell receptors activation, K+ to regulate stem cell differentiation, Mn2+ to activate the STING pathway, and Fe2+/3+ to induce tumor ferroptosis and enhance catalytic therapy, make the metal ions and metal‐based nanomaterials play crucial roles in the cancer treatments. Therefore, due to the superior advantages of metal‐based nanomaterials and the characteristics of the tumor microenvironment, we will summarize the recent progress of the anti‐tumor biological effects of metal‐based nanomaterials. Based on the different effects of metal‐based nanomaterials on tumor cells, this review mainly focuses on the following five aspects: (1) metal‐enhanced radiotherapy sensitization, (2) metal‐enhanced catalytic therapy, (3) metal‐enhanced ferroptosis, (4) metal‐enhanced pyroptosis, and (5) metal‐enhanced immunotherapy. At the same time, the shortcomings of the biological effects of metal‐based nanomaterials on tumor therapy are also discussed, and the future research directions have been prospected. The highlights of promising biosafety, potent efficacy on biological effects for tumor therapy, and the in‐depth various biological effects mechanism studies of metal‐based nanomaterials provide novel ideas for the future biological application of the nanomaterials.
Funder
National Natural Science Foundation of China
Collaborative Innovation Center of Suzhou Nano Science and Technology
Cited by
6 articles.
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