A phase 2 study of the PARP inhibitor veliparib plus temozolomide in patients with heavily pretreated metastatic colorectal cancer

Author:

Pishvaian Michael J.1ORCID,Slack Rebecca S.2,Jiang Wei3,He A. Ruth1,Hwang Jimmy J.3,Hankin Amy1,Dorsch-Vogel Karen1,Kukadiya Divyesh1,Weiner Louis M.1,Marshall John L.1,Brody Jonathan R.456

Affiliation:

1. Lombardi Comprehensive Cancer Center; Georgetown University Medical Center; Washington DC

2. The University of Texas MD Anderson Cancer Center; Houston Texas

3. Carolinas Medical Center; Charlotte North Carolina

4. Jefferson Pancreas, Biliary, and Related Cancer Center; Thomas Jefferson University; Philadelphia Pennsylvania

5. Department of Surgery; Thomas Jefferson University; Philadelphia Pennsylvania

6. Sidney Kimmel Cancer Center; Thomas Jefferson University; Philadelphia Pennsylvania

Funder

Ruesch Center for the Cure of Gastrointestinal Cancers at the Lombardi Comprehensive Cancer Center

AbbVie, Inc

National Institutes of Health

Pancreatic Cancer Action Network-American Association for Cancer Research Acceleration Network

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference52 articles.

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2. Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity;Ding;Cancer Res.,1994

3. Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology;Ratnam;Clin Cancer Res.,2007

4. Cancer chromosomes in crisis;DePinho;Nat Genet.,2004

5. Telomeres, stem cells, senescence, and cancer;Sharpless;J Clin Invest.,2004

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